Document Type : Review Article

Authors

1 Department of biological science, Faculty of Science, Kurdistan University, Sanandaj, Kurdistan, Iran

2 Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

3 Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa

4 Wellman Centre for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA

5 Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA

6 Australasian Nanoscience and Nanotechnology Initiative (ANNI), 8054 Monash University LPO, Clayton, Victoria 3168, Australia

7 Supreme Pharmatech Co. LTD, 399/90-95 Moo 13 Kingkaew Rd. Soi 25/1, T. Rachateva, A. Bangplee, Samutprakan 10540, Thailand

8 Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry; Regional University of Cariri; Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, Brazil

9 Laboratory of Microbiology and Molecular Biology; Department of Biological Chemistry; Regional University of Cariri; Rua Coronel Antônio Luis 1161, Pimenta, CEP 63105-000, Crato, Ceará, Brazil

10.55705/cmbr.2022.338888.1039

Abstract

Bacterial infections can be caused by contamination of labile blood products with specific bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Hospital equipment, bio-protective equipment, delivery systems, and medical devices can be easily contaminated by microorganisms. Multidrug-resistant bacteria can survive on various organic or inorganic polymeric materials for more than 90 days. Inhibiting the growth and eradicating these microorganisms is vital in blood transfusion processes. Blood bags and other related medical devices can be improved by the incorporation of organic or inorganic nanomaterials, particularly silicon dioxide (SiO2) nanoparticles. The addition of solid organic or inorganic nanoparticles to synthetic polymers or biopolymers can provide new properties in addition to antimicrobial activity. Among these NPs, formulations composed of SiO2 nanoparticles and polymers have been shown to improve the mechanical and antimicrobial properties of catheters, prosthetic inserts, blood bags, and other medical devices SiO2 nanoparticles possess several advantages, including large-scale synthetic availability, simple one-pot synthesis methods, porous structure for loading antibacterial agents, good biocompatibility, and thermal stability. Plasticized polyvinyl chloride is the main polymer, which has been functionalized by these nanoparticles. In this review, we discuss the recent advances and challenges regarding the functionalization of polyvinyl chloride by SiO2 nanoparticles to hinder bacterial contaminations in blood products.  

Graphical Abstract

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Keywords

Main Subjects

Selected author of this article by journal

ِDr. Michael R Hamblin
University of Johannesburg

GoogleScholar(H Index=138); Publons(H Index=109)

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