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Effect of vitamin D supplementation on glycemic control in type 1 diabetes mellitus

Articles in Press

Document Type : Original Article

Authors

1 M.B.CH.B., F.I.C.M.S., Pediatric Consultant, Membership of Clinical Nutrition, Ghazi Al-Hariri Hospital for Surgical Specialties, Ministry of Health, Baghdad, Iraq

2 M.B.CH.B., F.I.C.M.S., Community Medicine Consultant, Ghazi Al-Hariri Hospital for Surgical Specialties, Ministry of Health, Baghdad, Iraq

10.55705/cmbr.2024.436594.1218

Abstract

Diabetes mellitus is a group of metabolic diseases with high prevalence, mortality and morbidity characterized by prolonged high blood glucose concentrations resulting from defects in insulin secretion, insulin action, or both. This study aimed to assess the role of vitamin D supplementation in glycemic control in uncontrolled type 1 diabetes with vitamin D deficiency. It is a prospective study between 1st of October 2022 to 31st of July 2023, where ninety patients (male: female ratio 1:1) with uncontrolled type 1 diabetes and vitamin D deficiency attended The Specialized Center for Endocrinology and Diabetes in Baghdad Government-Iraq, their ages between 5-18 years were followed for 10months to assess their Hemoglobin A1c (Hba1c) and serum calcium after correction of vitamin D level with therapeutic doses of vitamin D. The findings of the study had shown that 41.1% of the patients had vitamin D insufficiency and 58.9% with deficiency regardless sex and age. All the obese children and 66.4% of the overweight had vitamin D deficiency with significant correlation with BMI (P<0.001). The severity of vitamin D was also related to duration of disease diagnoses (P<0.001). Good glycemic control occurs in patients with vitamin D levels>50ng/ml (P<0.01). In 14.5% of the patients after 6 months, their vitamin D levels again became deficient, so re-check was needed after 6 months from the end of the loading therapy. Vitamin D deficiency among the patients of diabetes mellitus type 1 was high and was closely related to glycemic control. The level of vitamin D was negatively related to the body weight and the duration of the disease. Additionally, the findings of the study have demonstrated therapeutic dose of vitamin D has the potential to manage glucose levels.

Graphical Abstract

Effect of vitamin D supplementation on glycemic control in type 1 diabetes mellitus

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Selected author of this article by journal

Dr. Mohammed Shaker Al-Awady
Ghazi Al-Hariri Hospital For Surgical Specialties

ORCID

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Cellular, Molecular and Biomedical Reports

Articles in Press, Accepted Manuscript
Available Online from 01 December 2024
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  • Receive Date: 06 October 2023
  • Revise Date: 26 December 2023
  • Accept Date: 21 January 2024
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