Document Type : Original Article
Authors
Department of Biochemistry, Payame Noor university, Tehran, Iran
Abstract
Diabetes Type 2 is the most common type of diabetes, a common disorder of glucose homeostasis and accounts for 90% of cases. The prevalence of diabetes type 2 is increasing. Adenosine deaminase is an enzymatic polymorphism that plays an important role in modulating the biological activity of insulin. It seems that excessive activity of the adenosine A1 receptor has caused adiposity in diabetes type 2. In this study, we examined the correlation of ADA enzyme with diabetes type 2. This investigation was performed on 80 men and women between 40 and 80 years old in District 2 of Tehran with diabetes. Venous blood samples were collected after 12 hours of fasting blood was centrifuged. Then fasting blood glucose and HbA1c, Triglyceride, and total Cholesterol were measured for enzyme activity respectively by COBAS MIRA. Insulin was measured by ELISA and serum ADA enzyme activity was measured by photometry. The results of this study were done by SPSS software. A significant increase in serum ADA levels was observed in diabetic patients compared with the control group. A positive correlation was observed between ADA activity and FBS and HbA1c. The amount of HOMA-IR in diabetics was higher than in the control group, but no positive correlation was observed between serum levels of ADA and HOMA-IR. The enzyme adenosine deaminase can act as an immunological marker and the results of this study show that diabetes is associated with increased T cell activation markers and immune disequilibrium. Serum ADA level has a positive correlation with glycemic control status in patients.
Keywords
Main Subjects
Selected author of this article by journal
Payame Noor university
Open Access
This article is licensed under a CC BY License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit: http://creativecommons.org/licenses/by/4.0/
Publisher’s Note
CMBR journal remains neutral with regard to jurisdictional claims in published maps and institutional afflictions.
Letters to Editor
Given that CMBR Journal's policy in accepting articles will be strict and will do its best to ensure that in addition to having the highest quality published articles, the published articles should have the least similarity (maximum 15%). Also, all the figures and tables in the article must be original and the copyright permission of images must be prepared by authors. However, some articles may have flaws and have passed the journal filter, which dear authors may find fault with. Therefore, the editor of the journal asks the authors, if they see an error in the published articles of the journal, to email the article information along with the documents to the journal office.
CMBR Journal welcomes letters to the editor ([email protected], [email protected]) for the post-publication discussions and corrections which allows debate post publication on its site, through the Letters to Editor. Critical letters can be sent to the journal editor as soon as the article is online. Following points are to be considering before sending the letters (comments) to the editor.
[1] Letters that include statements of statistics, facts, research, or theories should include appropriate references, although more than three are discouraged.
[2] Letters that are personal attacks on an author rather than thoughtful criticism of the author’s ideas will not be considered for publication.
[3] There is no limit to the number of words in a letter.
[4] Letter writers should include a statement at the beginning of the letter stating that it is being submitted either for publication or not.
[5] Anonymous letters will not be considered.
[6] Letter writers must include Name, Email Address, Affiliation, mobile phone number, and Comments.
[7] Letters will be answered as soon as possible.
)