Document Type : Meta Analysis


1 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

2 Division of Neurology, School of Medicine, Sheikh Shakhbout Medical City, Abu Dhabi, UAE

3 Department of Neuro Sciences, School of Medicine, Shahid Beheshti University Medical of Science, Tehran, Iran

4 Department of Neuro Sciences, School of Medicine, Tehran University Medical of Science, Tehran, Iran

5 Department of Neuro Sciences, School of Medicine, Iran University Medical of Science, Tehran, Iran



Abnormalities of several oncogenes and tumor suppressor genes have been identified in carcinomas during the last decade and of pathological warfare and physiological traits, and multiple genetic changes have been demonstrated in individual carcinomas. We conducted a systematic review of studies enrolling adolescents and adults with Carcinoma, every type in which a cancer intervention was randomized, or all study designs in which there was a primary or secondary outcome. We searched Ovid MEDLINE, EMBASE, and Evidence-Based Medicine Reviews from 1990 to June 2015. Two reviewers evaluated study eligibility and abstracted data. In total, 67 studies were included and consisted of 62 randomized trials, reviews, and 5 studies. None of the studies (0/81) provided a definition. Only one randomized trial provided a definition. We were unable to identify any definitions used in studies of adolescents and adults with Carcinoma. Given that a proportion of this population may receive intensive treatment, there is an urgent need for consensus-based definitions of use across trials and review systematic & and meta-analysis.

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Structural carcinoma overall process: a systematic review


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Dr. Ali Reza Arabestanino
Harvard Medical School

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