Document Type : Original Article


1 Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China

2 Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China


Stress granules (SGs) will be produced when the body is under external stimuli, and SGs play an important role in the pathogenesis of more and more diseases. The study on SGs has generally grown to a comprehensive subject in the past 35 years (from 1988 to 2022). The bibliometric analysis was used to comprehensively analyze the progress and development trend of SGs research. The literature output in the field of peritoneal dialysis showed a fluctuating growth in the past 35 years, and the last five years were the peak period of literature output. Journal of virology was the most widely published journal on SGs. And the most common research category was Biochemistry Molecular Biology. No matter in terms of the number of papers, citation frequency, H-index, or the distribution of journals and funding sources, the United States was far away from leading. With the enhancement of economic and scientific research strength, China has gradually carried out research on SGs. However, the citation frequency and H-index of Chinese papers were relatively low. Research cooperation between research institutions was relatively close, but domestic research institutions had less cooperation with relevant international institutions. The cooperation among authors was relatively scattered, and further exchanges and cooperation between scholars were needed for Chinese scholars. There are more and more reports about SGs, but there was still a big gap between China and the United States in the study of SGs.

Graphical Abstract

The progress and development trends on stress granules in the world and China during the past 35 years


Main Subjects

Selected author of this article by journal

ِDr. Yao Wang
Renmin Hospital of Wuhan University

Web of Science


Home page

Open Access

This article is licensed under a CC BY License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit:


Publisher’s Note

CMBR journal remains neutral with regard to jurisdictional claims in published maps and institutional afflictions.


Letters to Editor

Given that CMBR Journal's policy in accepting articles will be strict and will do its best to ensure that in addition to having the highest quality published articles, the published articles should have the least similarity (maximum 15%). Also, all the figures and tables in the article must be original and the copyright permission of images must be prepared by authors. However, some articles may have flaws and have passed the journal filter, which dear authors may find fault with. Therefore, the editor of the journal asks the authors, if they see an error in the published articles of the journal, to email the article information along with the documents to the journal office.

CMBR Journal welcomes letters to the editor ([email protected], [email protected]) for the post-publication discussions and corrections which allows debate post publication on its site, through the Letters to Editor. Critical letters can be sent to the journal editor as soon as the article is online. Following points are to be considering before sending the letters (comments) to the editor.

[1] Letters that include statements of statistics, facts, research, or theories should include appropriate references, although more than three are discouraged.

[2] Letters that are personal attacks on an author rather than thoughtful criticism of the author’s ideas will not be considered for publication.

[3] There is no limit to the number of words in a letter.

[4] Letter writers should include a statement at the beginning of the letter stating that it is being submitted either for publication or not.

[5] Anonymous letters will not be considered.

[6] Letter writers must include Name, Email Address, Affiliation, mobile phone number, and Comments.

[7] Letters will be answered as soon as possible.

  1. Simpson-Holley M, Kedersha N, Dower K, Rubins K, Anderson P, Hensley L, Connor J (2011) Formation of antiviral cytoplasmic granules during orthopoxvirus infection. Journal of virology 85 (4): 1581-1593. doi:
  2. Anderson P, Kedersha N (2008) Stress granules: the Tao of RNA triage. Trends in biochemical sciences 33 (3): 141-150. doi:
  3. Takahashi M, Higuchi M, Matsuki H, Yoshita M, Ohsawa T, Oie M, Fujii M (2013) Stress granules inhibit apoptosis by reducing reactive oxygen species production. Molecular and cellular biology 33 (4): 815-829. doi:
  4. Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K (2012) Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PloS one 7 (8): e43031. doi:
  5. Takahara T, Maeda T (2012) Transient sequestration of TORC1 into stress granules during heat stress. Molecular cell 47 (2): 242-252. doi:
  6. Thedieck K, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid S-N, Kremmer E (2013) Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell 154 (4): 859-874. doi:
  7. Onomoto K, Yoneyama M, Fung G, Kato H, Fujita T (2014) Antiviral innate immunity and stress granule responses. Trends in immunology 35 (9): 420-428. doi:
  8. Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A (2019) DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature 573 (7775): 590-594. doi:
  9. Gao X, Jiang L, Gong Y, Chen X, Ying M, Zhu H, He Q, Yang B, Cao J (2019) Stress granule: A promising target for cancer treatment. British journal of pharmacology 176 (23): 4421-4433. doi:
  10. Li YR, King OD, Shorter J, Gitler AD (2013) Stress granules as crucibles of ALS pathogenesis. Journal of cell biology 201 (3): 361-372. doi:
  11. Ravel-Chapuis A, Klein Gunnewiek A, Bélanger G, Crawford Parks TE, Côté J, Jasmin BJ (2016) Staufen1 impairs stress granule formation in skeletal muscle cells from myotonic dystrophy type 1 patients. Molecular biology of the cell 27 (11): 1728-1739. doi:
  12. Paul S, Dansithong W, Figueroa KP, Scoles DR, Pulst SM (2018) Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Nature communications 9 (1): 3648. doi:
  13. Linder B, Plöttner O, Kroiss M, Hartmann E, Laggerbauer B, Meister G, Keidel E, Fischer U (2008) Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. Human molecular genetics 17 (20): 3236-3246. doi:
  14. Bernard C, Pommier R, Vilgrain V, Ronot M (2020) Gender gap in articles published in European Radiology and CardioVascular and Interventional Radiology: evolution between 2002 and 2016. European Radiology 30: 1011-1019. doi:
  15. Jin B, Wu XA, Du SD (2020) Top 100 most frequently cited papers in liver cancer: a bibliometric analysis. ANZ Journal of Surgery 90 (1-2): 21-26. doi:
  16. Yang W, Zhang J, Ma R (2020) The prediction of infectious diseases: A bibliometric analysis. International Journal of Environmental Research and Public Health 17 (17): 6218. doi:
  17. Akmal M, Hasnain N, Rehan A, Iqbal U, Hashmi S, Fatima K, Farooq MZ, Khosa F, Siddiqi J, Khan MK (2020) Glioblastome multiforme: a bibliometric analysis. World neurosurgery 136: 270-282. doi:
  18. De Felice F, Polimeni A (2020) Coronavirus disease (COVID-19): a machine learning bibliometric analysis. in vivo 34 (3 suppl): 1613-1617. doi:
  19. Loomes DE, van Zanten SV (2013) Bibliometrics of the top 100 clinical articles in digestive disease. Gastroenterology 144 (4): 673-676. e675. doi:
  20. Murdayanti Y, Khan MNAA (2021) The development of internet financial reporting publications: A concise of bibliometric analysis. Heliyon 7 (12). doi:
  21. Carrión-Mero P, Montalván-Burbano N, Morante-Carballo F, Quesada-Román A, Apolo-Masache B (2021) Worldwide research trends in landslide science. International journal of environmental research and public health 18 (18): 9445. doi:
  22. van Eck NJ, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84 (2): 523-538. doi:
  23. Banani SF, Lee HO, Hyman AA, Rosen MK (2017) Biomolecular condensates: organizers of cellular biochemistry. Nature reviews Molecular cell biology 18 (5): 285-298. doi:
  24. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G, Ying Z (2015) Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity. Human molecular genetics 24 (9): 2426-2441. doi:
  25. Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J (2012) Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149 (4): 753-767. doi:
  26. Zhao YG, Codogno P, Zhang H (2021) Machinery, regulation and pathophysiological implications of autophagosome maturation. Nature Reviews Molecular Cell Biology 22 (11): 733-750. doi:
  27. Wang B, Maxwell BA, Joo JH, Gwon Y, Messing J, Mishra A, Shaw TI, Ward AL, Quan H, Sakurada SM (2019) ULK1 and ULK2 regulate stress granule disassembly through phosphorylation and activation of VCP/p97. Molecular cell 74 (4): 742-757. e748. doi:
  28. Omer A, Patel D, Moran JL, Lian XJ, Di Marco S, Gallouzi I-E (2020) Autophagy and heat-shock response impair stress granule assembly during cellular senescence. Mechanisms of Ageing and Development 192: 111382. doi:
  29. Jefferson M, Bone B, Buck JL, Powell PP (2019) The autophagy protein ATG16L1 is required for sindbis virus-induced eIF2α phosphorylation and stress granule formation. Viruses 12 (1): 39. doi:
  30. Chitiprolu M, Jagow C, Tremblay V, Bondy-Chorney E, Paris G, Savard A, Palidwor G, Barry FA, Zinman L, Keith J (2018) A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy. Nature communications 9 (1): 2794. doi:
  31. Kwon S, Zhang Y, Matthias P (2007) The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes & development 21 (24): 3381. doi:
  32. Gallouzi I-e, Parker F, Chebli K, Maurier F, Labourier E, Barlat I, Capony J-P, Tocque B, Tazi J (1998) A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. Molecular and cellular biology 18 (7): 3956-3965. doi:
  33. Gal J, Chen J, Na D-Y, Tichacek L, Barnett KR, Zhu H (2019) The acetylation of lysine-376 of G3BP1 regulates RNA binding and stress granule dynamics. Molecular and cellular biology 39 (22): e00052-00019. doi:
  34. Saito M, Iestamantavicius V, Hess D, Matthias P (2021) Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules. In: Boudvillain M (ed) RNA Remodeling Proteins: Methods and Protocols. Springer US, New York, NY, pp 217-234. doi:
  35. Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W (2020) HDAC6, a novel cargo for autophagic clearance of stress granules, mediates the repression of the Type I interferon response during coxsackievirus A16 infection. Frontiers in Microbiology 11: 78. doi:
  36. Wolozin B, Ivanov P (2019) Stress granules and neurodegeneration. Nature Reviews Neuroscience 20 (11): 649-666. doi:
  37. Legrand N, Dixon DA, Sobolewski C (2020) Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications. World journal of gastroenterology 26 (35): 5223. doi:
  38. Shahsavari M, Mohammadabadi M, Khezri A, Asadi Fozi M, Babenko O, Kalashnyk O, Oleshko V, Tkachenko S (2021) Correlation between insulin-like growth factor 1 gene expression and fennel (Foeniculum vulgare) seed powder consumption in muscle of sheep. Anim Biotechnol: 1-11. doi:
  39. Cao X, Jin X, Liu B (2020) The involvement of stress granules in aging and aging‐associated diseases. Aging cell 19 (4): e13136. doi:
  40. Vonaesch P, Sansonetti PJ, Schnupf P (2017) Immunofluorescence Analysis of Stress Granule Formation after Bacterial Challenge of Mammalian Cells. JoVE (Journal of Visualized Experiments)(125): e55536. doi: