Document Type : Original Article
1 Centre of Research for Development University of Kashmir Srinagar-190006, Kashmir, India
2 Department of Botany, Punjabi University Patiala, Punjab 147002, India
3 Department of Environmental Science, GDC Eidgah Srinagar J&K, Kashmiri, India
Most of the plants are essential due to their medicinal properties and have contributed to the origin and evolution of many traditional herbal therapies. Rheum is also one of the famous and known medicinal plants of Kashmir Himalaya. It ranges from an altitude of 1700-5500 m. Its Roots are long and stout. The stem is erect, hollow, sulcate, glabrous, or strigose. It is native to Asia-Temperate to Asia-Tropical, from China to India, Nepal, and Pakistan. In India, its found in Himachal Pradesh, Jammu and Kashmir, and Uttar Pradesh. Rhubarb is the English name of the genus Rheum (family Polygonaceae). Emodi, Webbianum and Spiciforme are three species of Rheum found in Kashmir Himalaya. Rheum species are well-known medicinal plant and is found on high altitudes. Its leaves and stalks are taken as food and cooked as vegetables. It’s used as medicine and is generally proven more effective against certain ailments like antibacterial, anticancerous, anti-inflammatory, rheumatoid diseases, stomachache, and intestinal problems. It is also used for the treatment of indigestion, abdominal disorders, boils, wounds and flatulence. But Rheum has become endangered due to exploitation. Active compounds like aloe-emodin, rhein, emodin, chrysaphanol and physicion are found in this plant which is anti Cancerian agents. High molecular diversity is also observed in all the three species of Rheum.
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- Tabin S, Kamili AN, Gupta R, Parray JA, Bansal A (2018) In vitro culture of Rheum emodi Wall: An endangered medicinal plant of Northwestern Himalaya. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 88(3):995-1006. doi:https://doi.org/10.1007/s40011-016-0835-7
- Stewart RR, Ali S, Nasir E (1972) An annotated catalogue of the vascular plants of West Pakistan and Kashmir. Printed at Fakhri Print. Press,
- Phartyal SS, Thapliyal R, Koedam N, Godefroid S (2002) Ex situ conservation of rare and valuable forest tree species through seed-gene bank. Current Science 83(11):1351-1357
- Rolta R, Salaria D, Sharma P, Sharma B, Kumar V, Rathi B, Verma M, Sourirajan A, Baumler DJ, Dev K (2021) Phytocompounds of Rheum emodi, Thymus serpyllum, and Artemisia annua inhibit spike protein of SARS-CoV-2 binding to ACE2 receptor: in silico approach. Current pharmacology reports 7(4):135-149. doi:https://doi.org/10.1007/s40495-021-00259-4
- Gowthami R, Sharma N, Pandey R, Agrawal A (2021) Status and consolidated list of threatened medicinal plants of India. Genetic Resources and Crop Evolution 68(6):2235-2263. doi:https://doi.org/10.1007/s10722-021-01199-0
- Chaurasia OP, Ahmed Z, Ballabh B (2007) Ethnobotany and plants of trans-Himalaya. Satish Serial Pub. House, Delhi, India.
- Shakya AK (2020) Drug-induced hepatotoxicity and hepatoprotective medicinal plants: a review. Indian J Pharm Educ Res 54(2):234-250. doi:https://doi.org/10.5530/ijper.54.2.28
- Kasiri MB, Safapour S (2013) Natural Dyes and Antimicrobials for Textiles. In: Lichtfouse E, Schwarzbauer J, Robert D (eds) Green Materials for Energy, Products and Depollution. Springer Netherlands, Dordrecht, pp 229-286. doi:https://doi.org/10.1007/978-94-007-6836-9_6
- Vanita P, Kiran D, Madhu S, Amita B, Paramvir SA (2012) Propagation of Picrorhiza kurroa Royle ex Benth: An important medicinal plant of Western Himalaya. Journal of Medicinal Plants Research 6(34):4848-4860. doi:https://doi.org/10.5897/JMPR12.115
- Khan MI, Shahzad A, Ganie IB, Pandith SA (2022) Organogenesis, direct somatic embryogenesis, and shoot proliferation of Rheum spiciforme Royle: an endemic and vulnerable medicinal herb from Indian Trans Himalayas. In Vitro Cellular & Developmental Biology-Plant 58(1):35-50. doi:https://doi.org/10.1007/s11627-021-10211-2
- Ganie AH, Tali BA, Khuroo AA, Nawchoo IA, Rather AM (2014) Rheum spiciforme Royle (Polygonaceae): a new record to the flora of Kashmir Valley, India. National Academy Science Letters 37(6):561-565. doi:https://doi.org/10.1007/s40009-014-0279-7
- Tabin S, Kamili AN, Ganie SA, Zargar O, Sharma V, Gupta RC (2016) Genetic diversity and population structure of Rheum species in Kashmir Himalaya based on ISSR markers. Flora 223:121-128. doi:https://doi.org/10.1016/j.flora.2016.05.001
- Krenn L, Pradhan R, Presser A, Reznicek G, Kopp B (2004) Anthrone C-glucosides from Rheum emodi. Chemical and Pharmaceutical Bulletin 52(4):391-393. doi:https://doi.org/10.1248/cpb.52.391
- Wang L-S, Stoner GD (2008) Anthocyanins and their role in cancer prevention. Cancer letters 269(2):281-290. doi:https://doi.org/10.1016/j.canlet.2008.05.020
- Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N (2019) A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery. Metabolites 9(11):258. doi:https://doi.org/10.3390/metabo9110258
- Giannenas I, Sidiropoulou E, Bonos E, Christaki E, Florou-Paneri P (2020) The history of herbs, medicinal and aromatic plants, and their extracts: Past, current situation and future perspectives. In: Feed additives. Elsevier, pp 1-18. doi:https://doi.org/10.1016/B978-0-12-814700-9.00001-7
- Ahmed SR, Rabbee MF, Roy A, Chowdhury R, Banik A, Kubra K, Hassan Chowdhury MM, Baek K-H (2021) Therapeutic promises of medicinal plants in Bangladesh and their bioactive compounds against ulcers and inflammatory diseases. Plants 10(7):1348. doi:https://doi.org/10.3390/plants10071348
- Srinivas G, Babykutty S, Sathiadevan PP, Srinivas P (2007) Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Medicinal research reviews 27(5):591-608. doi:https://doi.org/10.1002/med.20095
- Tayade A, Dhar P, Ballabh B, Kumar R, Chaurasia O, Bhatt R, Srivastava R (2012) Rheum webbianum royle: A potential medicinal plant from trans-himalayan cold deserts of Ladakh, India. Plant Archives 12(2):603-606
- Cai Y, Sun M, Xing J, Corke H (2004) Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: Structure− radical scavenging activity relationships. Journal of agricultural and food chemistry 52(26):7884-7890. doi:https://doi.org/10.1021/jf0489116
- Semple SJ, Pyke SM, Reynolds GD, Flower RL (2001) In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral research 49(3):169-178
- Alam MA, Javed K, Jafri M (2005) Effect of Rheum emodi (Revand Hindi) on renal functions in rats. Journal of Ethnopharmacology 96(1-2):121-125. doi:https://doi.org/10.1016/j.jep.2004.08.028
- Akhtar M, Amin M, Ahmad M, Alamgeer A (2009) Hepatoprotective effect of Rheum emodi roots (Revand chini) and Akseer-e-Jigar against paracetamol-induced hepatotoxicity in rats. Ethnobotanical leaflets 2009(2):310-315
- Ho T-Y, Wu S-L, Chen J-C, Li C-C, Hsiang C-Y (2007) Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral research 74(2):92-101. doi:https://doi.org/10.1016/j.antiviral.2006.04.014
- Radhika R, Kumari D, Sudarsanam D (2010) Antidiabetic activity of Rheum emodi in alloxan induced diabetic rats. Int J Pharm Sci Res 8:296-300
- Kuo P-L, Lin T-C, Lin C-C (2002) The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life sciences 71(16):1879-1892. doi:https://doi.org/10.1016/S0024-3205(02)01900-8
- Rajkumar V, Guha G, Ashok Kumar R (2010) Antioxidant and anti-cancer potentials of Rheum emodi rhizome extracts. Evidence Based Complementary and AlternativeMedicine 2011:28-35; ID: 697986. doi:https://doi.org/10.1093/ecam/neq048.
- Kala CP (2002) Indigenous knowledge of Bhotiya tribal community on wool dyeing and its present status in the Garhwal Himalaya, India. Current Science 83(7):814-817
- Malik S, Kumar R, Vats SK, Bhushan S, Sharma M, Ahuja PS (2009) Regeneration in Rheum emodi Wall.: a step towards conservation of an endangered medicinal plant species. Engineering in life sciences 9(2):130-134. doi:https://doi.org/10.1002/elsc.200800071
- Rezaei-Nasab M, Komeili G, Fazeli-Nasab B (2017) Gastroprotective effects of aqueous and hydroalcholic extract of Scrophularia striata on ethanol-induced gastric ulcers in rats. Der Pharmacia Lettre 9(5):84-93
- Fazeli-Nasab B, Sirousmehr A, Mirzaei N, Solimani M (2017) Evaluation of total phenolic, flavenoeid content and antioxidant activity of Leaf and Fruit in 14 different genotypes of Ziziphus mauritiana L. in south of Iran. Eco-Phytochemical Journal of Medicinal Plants 4(4):1-14
- Fazeli-Nasab B (2018) The effect of explant, BAP and 2,4-D on callus induction of trachyspermum ammi. Potravinarstvo Slovak Journal of Food Sciences 12(1):578-586. doi:https://doi.org/10.5219/953
- Balandrin MF, Kinghorn AD, Farnsworth NR (1993) Plant-derived natural products in drug discovery and development: an overview. In, vol Vol. 534. ACS Symposium Series. doi:https://doi.org/10.1021/bk-1993-0534.ch001
- Zargar BA, Masoodi MH, Ahmed B, Ganie SA (2011) Phytoconstituents and therapeutic uses of Rheum emodi wall. ex Meissn. Food chemistry 128(3):585-589. doi:https://doi.org/10.1016/j.foodchem.2011.03.083
- Lu L-M, Mao L-F, Yang T, Ye J-F, Liu B, Li H-L, Sun M, Miller JT, Mathews S, Hu H-H (2018) Evolutionary history of the angiosperm flora of China. Nature 554(7691):234-238. doi:https://doi.org/10.1038/nature25485
- Monro AK, Bystriakova N, Fu L, Wen F, Wei Y (2018) Discovery of a diverse cave flora in China. PloS one 13(2):e0190801. doi:https://doi.org/10.1371/journal.pone.0190801
- Khuroo AA, Rashid I, Reshi Z, Dar GH, Wafai B (2007) The alien flora of Kashmir Himalaya. Biological Invasions 9(3):269-292. doi:https://doi.org/10.1007/s10530-006-9032-6