Document Type : Original Article

Authors

1 Department of Radiology, Zabol University of Medical Sciences, Zabol, Islamic Republic of Iran

2 Department of Obstetrics and Gynecology, School of Medicine, Medicinal Plants Research Center, Amir al momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran

10.55705/cmbr.2022.336572.1036

Abstract

Diabetes is one of the most common non-contagious diseases in the world. This disease is the fourth or fifth cause of death in most developed countries. The relationship between tuberculosis and diabetes had been introduced years ago and diabetes is considered a threatening factor in tuberculosis in the research history. Not only tuberculosis is prevalent among diabetic persons, but also diabetes can affect the appearance of imaging of tuberculosis. This is a kind of analytic study, a case-control study, which was carried out between the years 2014 and 2015 in Zabol City. In this study, the radiographic findings from the patients suffering from pulmonary tuberculosis in diabetic patients and not diabetic patients are compared. These radiographic were handed to a radiologist and the radiologic findings of these graphs from the anatomic location (upper and lower half of the right and left bellows), Presence or absence of cavities, nodules, density and pleural involvement were recorded and compared with the diabetic and non-diabetic group. After gathering of the data using SPSS software, descriptive statistics were presented in the form of (frequency, percent) graphs and a chi-square test (p<0.05) was used to analyze and comparing of the results of diabetic and un-diabetic patients. The population of the study consisted of Chest radiographs for 124 TB patients which 61 (49.19 %) were suffering from diabetics. In this study, 45 (71.43%) non-diabetic and 42 (65.85%) diabetic patients were women (p=0.7). There were 12 diabetic TB patients (19.67%) and 3 non-diabetic- TB patients (4.76%) with the consolidation of middle part of left lung (p=0.01) and 8 (13.11%) diabetic TB and 1 (1.59%) non-diabetic TB with reticulonodular infiltration of lower part of left lung (p=0.02). There was no significant difference in the rest of the radiographic results. The findings of this study indicate that reticulonodular infiltration and consolidation of lower &middle parts of the lung in TB diabetic patients is more than in TB non-diabetic patients and diabetes can affect the findings of pulmonary tuberculosis radiography. 

Graphical Abstract

Evaluation of Active Pulmonary Tuberculosis Among Women With Diabetes

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ِDr. Khadije Rezaie Keikhaie
Zabol university of medical sciences

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  1. Rahbar-Karbasdehi E, Rahbar-Karbasdehi F (2021) Clinical challenges of stress cardiomyopathy during coronavirus 2019 epidemic. Cellular, Molecular and Biomedical Reports 1(2):88-90. doi:https://doi.org/10.55705/cmbr.2021.145790.1018
  2. Aubais aljelehawy Qh, Hadi Alshaibah LH, Abbas Al- Khafaji ZK (2021) Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital. Cellular, Molecular and Biomedical Reports 1(2):78-87. doi:https://doi.org/10.55705/cmbr.2021.144995.1017
  3. Almasian-Tehrani N, Alebouyeh M, Armin S, Soleimani N, Azimi L, Shaker-Darabad R (2021) Overview of typing techniques as molecular epidemiology tools for bacterial characterization. Cellular, Molecular and Biomedical Reports 1(2):69-77. doi:https://doi.org/10.55705/cmbr.2021.143413.1016
  4. Abbas-Al-Khafaji ZK, Aubais-aljelehawy Qh (2021) Evaluation of antibiotic resistance and prevalence of multi-antibiotic resistant genes among Acinetobacter baumannii strains isolated from patients admitted to al-yarmouk hospital. Cellular, Molecular and Biomedical Reports 1(2):60-68. doi:https://doi.org/10.55705/cmbr.2021.142761.1015
  5. Alavi M, Rai M (2021) Antisense RNA, the modified CRISPR-Cas9, and metal/metal oxide nanoparticles to inactivate pathogenic bacteria. Cellular, Molecular and Biomedical Reports 1(2):52-59. doi:https://doi.org/10.55705/cmbr.2021.142436.1014
  6. Nasehi M, Mirhaghani L (2010) National union against tuberculosis guideline. Tehran: Health ministry 3(3):22-25
  7. Tripathy S, Kar K, Chakraborty D, Majumdar A (1984) Diabetes mellitus and pulmonary tuberculosis. A prospective study. Ind J Tub 31(3):122-125
  8. Kermansaravi F, Metanat M (2012) Prevalence of Smear Positive Pulmonary Tuberculosis among Diabetic Patients in Southwest of Iran. Journal of Mazandaran University of Medical Sciences 22(87):97-103
  9. Ruslami R, Aarnoutse RE, Alisjahbana B, Van Der Ven AJ, Van Crevel R (2010) Implications of the global increase of diabetes for tuberculosis control and patient care. Tropical Medicine & International Health 15(11):1289-1299. doi:https://doi.org/10.1111/j.1365-3156.2010.02625.x
  10. Dooley KE, Chaisson RE (2009) Tuberculosis and diabetes mellitus: convergence of two epidemics. The Lancet Infectious Diseases 9(12):737-746. doi:https://doi.org/10.1016/S1473-3099(09)70282-8
  11. Alisjahbana B, Sahiratmadja E, Nelwan EJ, Purwa AM, Ahmad Y, Ottenhoff TH, Nelwan RH, Parwati I, Meer JWvd, Crevel Rv (2007) The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clinical infectious diseases 45(4):428-435. doi:https://doi.org/10.1086/519841
  12. Wang J-Y, Lee L, Hsueh P (2005) Factors changing the manifestation of pulmonary tuberculosis. The International Journal of Tuberculosis and Lung Disease 9(7):777-783
  13. Bashar M, Alcabes P, Rom WN, Condos R (2001) Increased incidence of multidrug-resistant tuberculosis in diabetic patients on the Bellevue Chest Service, 1987 to 1997. Chest 120(5):1514-1519. doi:https://doi.org/10.1378/chest.120.5.1514
  14. Al-Tawfiq J, Saadeh B (2009) Radiographic manifestations of culture-positive pulmonary tuberculosis: cavitary or non-cavitary? The International Journal of Tuberculosis and Lung Disease 13(3):367-370
  15. Perez-Guzman C, Torres-Cruz A, Villarreal-Velarde H, Salazar-Lezama M A, Vargas M H (2001) Atypical radiological images of pulmonary tuberculosis in 192 diabetic patients: a comparative study. The International Journal of Tuberculosis and Lung Disease 5(5):455-461
  16. Ruslami R, Nijland HM, Adhiarta IGN, Kariadi SH, Alisjahbana B, Aarnoutse RE, van Crevel R (2010) Pharmacokinetics of antituberculosis drugs in pulmonary tuberculosis patients with type 2 diabetes. Antimicrobial agents and chemotherapy 54(3):1068-1074. doi:https://doi.org/10.1128/AAC.00447-09
  17. Ponce-de-Leon A, Garcia-Garcia MdL, Garcia-Sancho MC, Gomez-Perez FJ, Valdespino-Gomez JL, Olaiz-Fernandez G, Rojas R, Ferreyra-Reyes L, Cano-Arellano B, Bobadilla M (2004) Tuberculosis and diabetes in southern Mexico. Diabetes care 27(7):1584-1590. doi:https://doi.org/10.2337/diacare.27.7.1584
  18. Tatar D, Senol G, Alptekin S, Karakurum C, Aydin M, Coskunol I (2009) Tuberculosis in diabetics: features in an endemic area. Jpn J Infect Dis 62(6):423-427
  19. Umut S, Tosun GA, Yildirim N (1994) Radiographic location of pulmonary tuberculosis in diabetic patients. Chest 106(1):326. doi:https://doi.org/10.1378/chest.106.1.326a
  20. Shaikh MA, Singla R, Khan NB, Sharif NS, Saigh MO (2003) Does diabetes alter the radiological presentation of pulmonary tuberculosis. Saudi medical journal 24(3):278-281. doi:PMID: 12704504
  21. Harayama N, Nihei S, Isa Y, Arai H, Shinjou T, Nagata K, Ueki M, Aibara K, Kamochi M (2011) Comparison of nifekalant and amiodarone for resuscitation after cardiopulmonary arrest due to shock-resistant ventricular fibrillation. Critical Care 15(1):P291. doi:10.1186/cc9711
  22. Chiang C, Slama K, Enarson D (2007) Associations between tobacco and tuberculosis [Educational Series: tobacco and tuberculosis. Serialised guide. Tobacco cessation interventions for tuberculosis patients. Number 1 in the series]. The International Journal of Tuberculosis and Lung Disease 11(3):258-262
  23. Jabbar A, Hussain S, Khan A (2006) Clinical characteristics of pulmonary tuberculosis in adult Pakistani patients with co-existing diabetes mellitus. Eastern Mediterranean Health Journal(EMHJ) 12(5):522-527
  24. Jeon CY, Murray MB (2008) Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies. PLOS Medicine 5(7):e152. doi:10.1371/journal.pmed.0050152
  25. Morris S, Bai GH, Suffys P, Portillo-Gomez L, Fairchok M, Rouse D (1995) Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. Journal of Infectious Diseases 171(4):954-960. doi:https://doi.org/10.1093/infdis/171.4.954
  26. Janmeja A, Das S, Bhargava R, Chavan B (2005) Psychotherapy improves compliance with tuberculosis treatment. Respiration 72(4):375-380. doi:https://doi.org/10.1159/000086251
  27. Mahabalshetti AD, Dhananjaya M, Aithal KR (2014) Lower lung field tuberculosis: a clinical study from tertiary care teaching hospital of North Karnataka.)
  28. Patel AK, Rami KC, Ghanchi FD (2011) Radiological presentation of patients of pulmonary tuberculosis with diabetes mellitus. Lung India 28(1):70. doi:https://doi.org/10.4103/0970-2113.76308
  29. Viswanathan V, Kumpatla S, Aravindalochanan V, Rajan R, Chinnasamy C, Srinivasan R, Selvam JM, Kapur A (2012) Prevalence of diabetes and pre-diabetes and associated risk factors among tuberculosis patients in India. PLoS ONE 7(7):e41367. doi:https://doi.org/10.1371/journal.pone.0041367
  30. Ikezoe J, Takeuchi N, Johkoh T, Kohno N, Tomiyama N, Kozuka T, Noma K, Ueda E (1992) CT appearance of pulmonary tuberculosis in diabetic and immunocompromised patients: comparison with patients who had no underlying disease. AJR American journal of roentgenology 159(6):1175-1179. doi:https://doi.org/10.2214/ajr.159.6.1442377