Document Type : Original Article
Pediatric Hematology and Oncology Department, Ardabil University of Medical Science, Ardabil, Iran.
Department of Pediatric, Faculty of medicine, Ardabil University of Medical Science, Ardabil, Iran
Center for Cell Pathology Research, Department of Biological Science, Khazar University, Baku, Azerbaijan
Department of Community Medicine, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran.
Department of Community Medicine, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
Center for Cell Pathology Research, Life Sciences Department, Khazar University, Baku, Azerbaijan.
Department of Molecular Genetic, Payam-e-Noor University, Tehran, Iran
Glucose-6-phosphate dehydrogenase (G6PD) is one of the most common genetic deficiencies that affect approximately 400 million people worldwide. This study aimed to identify neonates with G6PD deficiency in Ardabil province during 2017-2018. This cross-sectional study was conducted on all term and preterm newborns in Ardabil Province from April 2018 to April 2019. The sampling method was census and in study duration, 1044 newborns were entered in the study. For each infant, severe hyperbilirubinemia (total serum bilirubin equal or greater than 300 micromol/L) was tested by the diazo method and G6PD was evaluated by Fluorescent Spot Test (FST). Of all infants, 15 (1.4 %) were diagnosed to have G6PD deficiency by FST. The prevalence of G6PD deficiency was significantly in boys higher than in girls (80% vs. 20%, p=0.001). Of all infants, 97 (9.3%) had jaun dice 72 hours after birth that of them 7 neonates (7.2%) had G6PD deficiency. Results showed that the prevalence of G6PD deficiency in this study was less than in other places in Iran that may be because of different ethnicity and demographic features.
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- Kilicdag H, Gökmen Z, Ozkiraz S, Gulcan H, Tarcan A (2014) Is it accurate to separate glucose-6-phosphate dehydrogenase activity in neonatal hyperbilirubinemia as deficient and normal? Pediatrics & Neonatology 55:202-207. doi:https://doi.org/10.1016/j.pedneo.2013.10.006
- Al-Musawi BM, Al-Allawi N, Abdul-Majeed BA, Eissa AA, Jubrael JM, Hamamy H (2012) Molecular characterization of glucose-6-phosphate dehydrogenase deficient variants in Baghdad city-Iraq. BMC blood disorders 12:1-6. doi:https://doi.org/10.1186/1471-2326-12-4
- Moosazadeh M, Amiresmaili M, Aliramezany M (2014) Prevalence of G6PD deficiency in Iran, a mata-analysis. Acta medica Iranica 52:256-264
- Cappellini MD, Fiorelli G (2008) Glucose-6-phosphate dehydrogenase deficiency. The Lancet 371:64-74. doi:https://doi.org/10.1016/s0140-6736(08)60073-2
- Ahadi A, Mirzarahimi M, Ahmadabadi F, Tavasoli A, Parvaneh N (2013) Comparison of the efficacy of Clofibrate with Phenobarbital in decreasing neonatal hyperbilirubinemia. Iranian Journal of Neonatology IJN 4:13-19
- Tang J, Jiang C, Xiao X, Fang Z, Li L, Han L, Mei A, Feng Y, Guo Y, Li H (2015) Changes in red blood cell membrane structure in G6PD deficiency: An atomic force microscopy study. Clinica Chimica Acta 444:264-270. doi:https://doi.org/10.1016/j.cca.2015.02.042
- Pahlavanzadeh M, Hekmatimoghaddam S, Ardestani MT, Ghafoorzadeh M, Aminorraaya M (2013) G6PD enzyme deficiency in neonatal pathologic hyperbilirubinemia in Yazd. Iranian journal of pediatric hematology and oncology 3:69-72. doi:PMCID: PMC3915450; PMID: 24575273
- Mesner O, Hammerman C, Goldschmidt D, Rudensky B, Bader D, Kaplan M (2004) Glucose-6-phosphate dehydrogenase activity in male premature and term neonates. Archives of Disease in Childhood-Fetal and Neonatal Edition 89:F555-F557. doi:https://doi.org/10.1136/adc.2004.049148
- Liu H, Liu W, Tang X, Wang T (2015) Association between G6PD deficiency and hyperbilirubinemia in neonates: a meta-analysis. Pediatric hematology and oncology 32:92-98. doi:https://doi.org/10.3109/08880018.2014.887803
- Farhoud D, Yazdanpanah L (2008) Glucose-6-phosphate dehydrogenase (G6PD) Deficiency. Iranian Journal of Public Health 37:1-18
- Iranpour R, Hashemipour M, Talaei S-M, Soroshnia M, Amini A (2008) Newborn screening for glucose-6-phosphate dehydrogenase deficiency in Isfahan, Iran: a quantitative assay. Journal of medical screening 15:62-64. doi:https://doi.org/10.1258/jms.2008.008027
- Ghoreyshi S, Soltani AH, Ghoreyshi S (2007) Glucose-6-phosphate dehydrogenase deficiency in Icteric neonates admitted in Tabriz pediatric medical center. Medical Journal of Tabriz University of Medical Sciences 27:89-93
- Atay E, Bozaykut A, Ipek IO (2006) Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia. Journal of tropical pediatrics 52:56-58. doi:https://doi.org/10.1093/tropej/fmi042
- Iranpour R, Akbar M, Haghshenas I (2003) Glucose-6-phosphate dehydrogenase deficiency in neonates. The Indian Journal of Pediatrics 70:855-857. doi:https://doi.org/10.1007/bf02730581
- Kosaryan M, Mahdavi MR, Jalali H, Roshan P (2014) Why does the Iranian national program of screening newborns for G6PD enzyme deficiency miss a large number of affected infants? Pediatric hematology and oncology 31:95-100. doi:https://doi.org/10.3109/08880018.2013.871613
- Bhutani VK, Stark AR, Lazzeroni LC, Poland R, Gourley GR, Kazmierczak S, Meloy L, Burgos AE, Hall JY, Stevenson DK (2013) Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. The Journal of pediatrics 162:477-482. e471. doi:https://doi.org/10.1016/j.jpeds.2012.08.022
- Najib KS, Saki F, Hemmati F, Inaloo S (2013) Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in the South of iran (fars province). Iranian Red Crescent Medical Journal 15:260-263. doi:https://doi.org/10.5812/ircmj.3337
- Kavehmanesh Z, Ebrahimi-Mohammadieh N, Karimi-Zarchi AA, Amir SS, Z. K-M, Torkaman M (2008) Prevalence of readmission for hyperbilirubinemia in healthy newborns. Iranian Journal of Pediatrics 8:130-136
- Bhutani VK, Johnson L, Sivieri EM (1999) Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 103:6-14. doi:https://doi.org/10.1542/peds.103.1.6
- Tiberi E, Latella C, Parenti D, Romagnoli C (2007) Predictive ability of a predischarge hour-specific serum bilirubin for hyperbilirubinemia in full term infants. Minerva pediatrica 59:183-189. doi:PMID: 17519862
- Alpay F, Sarici SÜ, Tosuncuk HD, Serdar MA, Inanç N, Gökçay E (2000) The value of first-day bilirubin measurement in predicting the development of significant hyperbilirubinemia in healthy term newborns. Pediatrics 106:e16-e16. doi:https://doi.org/10.1542/peds.106.2.e16
- Abolghasemi H, Mehrani H, Amid A (2004) An update on the prevalence of glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Tehran neonates. Clinical biochemistry 37:241-244. doi:https://doi.org/10.1016/j.clinbiochem.2003.11.010
- Amoozegar H, Mirshakeri M, Paishva N (2005) Prevalence of Glucose-6-phosphate dehydrogenase deficiency among male donors in Shiraz, southern Iran. Iranian Journal of Medical Sciences 30:94-96
- Sinha R, Sachendra B, Syed VS, Nair L, John B (2017) To study the prevalence of glucose 6 phosphate dehydrogenase (G6PD) deficiency in neonates with neonatal hyperbilirubinemia and to compare the course of the neonatal jaundice in deficient versus non deficient neonates. Journal of Clinical Neonatology 6:71-74. doi:https://doi.org/10.4103/jcn.jcn_59_16
- M Abo El Fotoh WM, Rizk MS (2016) Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates. The Journal of Maternal-Fetal & Neonatal Medicine 29:3834-3837. doi:https://doi.org/10.3109/14767058.2016.1148133