Review Article
DNA, RNA, protein components
Yulu Han
Abstract
Autism, as a neurodevelopmental disorder, has become an important public health issue worldwide. The mechanisms by which DNA methylation regulates gene expression contributing to autism are complex and elaborate. As a non-invasive, highly accurate prenatal diagnosis, DNA methylation screening can be ...
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Autism, as a neurodevelopmental disorder, has become an important public health issue worldwide. The mechanisms by which DNA methylation regulates gene expression contributing to autism are complex and elaborate. As a non-invasive, highly accurate prenatal diagnosis, DNA methylation screening can be used to detect whether the fetus may be at risk for autism. However, the results of this approach require a professional bioinformatics analysis, and the diagnosis cannot be directly confirmed. Therefore, DNA methylation screening is often used as an adjunct to prenatal diagnosis rather than the only diagnostic basis. In practice, doctors will make a comprehensive judgment based on the results of DNA methylation screening, combined with other prenatal diagnosis methods, such as gene sequencing. Some studies have found a large number of DNA methylation abnormalities in the autistic brain, especially in genes related to neurodevelopment. These aberrant DNA methylation states may contribute to autism by affecting the expression of these genes, which in turn affects neuronal function and behavior. This study aimed to investigate the role of DNA methylation in autism and the application of detection techniques.
Original Article
Biochemistry
Lifeng Meng; Ping Zhou; Weifeng Xu; Wei Bian; Yunxiao Lin; Ying Guan
Abstract
Gout is a complex and common form of arthritis which has brought great inconveniences to the normal lives of patients worldwide. However, the molecular basis of gouty arthritis is still incompletely understood, which has limited the identification of therapeutic targets. Here we show that the Smad ubiquitin ...
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Gout is a complex and common form of arthritis which has brought great inconveniences to the normal lives of patients worldwide. However, the molecular basis of gouty arthritis is still incompletely understood, which has limited the identification of therapeutic targets. Here we show that the Smad ubiquitin regulatory factor 1 (Smurf1) is markedly lower in peripheral blood from human gouty arthritis patients. Smurf1 inhibitor A01 promoted mono-sodium urate (MSU) crystals-induced gouty arthritis. Mechanistic studies revealed that inhibition of Smurf1 promotes M1-like macrophage polarization through accelerating glycolysis, and the AMPK signaling pathway is involved in the regulatory role of Smurf1. In conclusion, Smurf1 acted as a suppressor in gouty arthritis, which might serve as a potential target for the therapies of gouty arthritis.
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