Original Article
Medical
Khadije Saravani; Zahra Mirsarzai; Monireh Sekhavati
Abstract
A cerebral aneurysm is an abnormal bulge in the cerebral artery that spreads where the blood vessel wall has weakened. Cerebral aneurysms may allow blood to leak into the subcutaneous space around the brain and cause damage to brain cells. Brain aneurysms can also be ruptured and can lead to serious ...
Read More
A cerebral aneurysm is an abnormal bulge in the cerebral artery that spreads where the blood vessel wall has weakened. Cerebral aneurysms may allow blood to leak into the subcutaneous space around the brain and cause damage to brain cells. Brain aneurysms can also be ruptured and can lead to serious and possibly fatal strokes. A cerebral aneurysm is known as swelling of a blood vessel in the brain. In the definition of these conditions, it is said that it looks like a hanging berry from a stem. In cases where most aneurysms do not rupture or cause health problems, samples that experience such conditions cause bleeding in the brain - hemorrhagic stroke. Intracranial hemorrhages have attracted much attention because of the increasing role of indirect maternal mortality and the importance of rapid diagnosis and treatment in reducing mortality, and since in many cases, they occur due to brain vascular aneurysm. The topic is also essential. When faced with an aneurysm in a pregnant woman, the decision about pregnancy, termination and termination is based on the indications of midwifery and decision-making about the diagnosis and treatment of aneurysm based on neurosurgical indications.
Original Article
Medical
Leli Rezaie-Kahkhaie; Khadije Saravani; Khadije Rezaie-Keikhaie; Seyed Esmaeil Azimi-Khatibani; Abdul Hafiz Daman-Sooz; Mehdi Afshari; Atefeh kamali
Abstract
Today, due to the increase in life expectancy in HIV-infected patients, the incidence of related diseases such as hepatitis B and C due to similarity in transmission routes has become a major concern of the health community. Therefore, this study was performed to determine the prevalence of hepatitis ...
Read More
Today, due to the increase in life expectancy in HIV-infected patients, the incidence of related diseases such as hepatitis B and C due to similarity in transmission routes has become a major concern of the health community. Therefore, this study was performed to determine the prevalence of hepatitis B among HIV + patients in Zabol. This descriptive cross-sectional study was performed on 37 HIV-infected patients in Zabol city (2021-2022). In the present study, HIV-infected patients were screened for hepatitis B by measuring serum levels of HBC Ab and HBs Ag. Finally, the data in SPSS V21 software were analyzed. In the present study, a total of 37 HIV-infected patients with a mean age of 40.81- 11.64 years were evaluated. The present study's prevalence of HIV and HCV co-infection was 21.6%. Also, 13.5% of HIV patients had HBV and HCV simultaneously. Examination of risk factors for viral hepatitis in HIV-infected patients showed that unprotected sex (100%), injecting drug use or IDU (87.5%), dental procedures (75%), history of imprisonment (62.5%) and tattooing (50.5%) were the most common factors in HIV patients. Family history of hepatitis B (12.5%), alcohol (12.5%), transfusion (12.5%) and cupping (25%) were among the lowest cases in these patients. the frequency of HBV infection and co-infection with HCV and HBV in HIV-positive patients were relatively high. Except for the history of tattoos, there is no significant relationship between other risk factors and hepatitis B among HIV-positive patients.
Original Article
Medical
Kolsoum Rezaie-Kahkhaie; Khadije Rezaie-Keikhaie; Leli Rezaie-Kahkhaie; Khadije Saravani; Atefeh kamali
Abstract
The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. This study aimed to investigate the association between IL23R 1142 G/A (Arg381Gln) and GM-CSF 3928 C/T (Ile117Thr) gene polymorphisms with the incidence rate of ...
Read More
The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. This study aimed to investigate the association between IL23R 1142 G/A (Arg381Gln) and GM-CSF 3928 C/T (Ile117Thr) gene polymorphisms with the incidence rate of tuberculosis in the population of Sistan. This study was based on the descriptive and applied type. All patients with active pulmonary tuberculosis were referred to the tuberculosis center of Zabol city for one year, with an equal number of healthy people adapted to the patients examined in terms of age. After data collecting to compare the frequency of polymorphisms, the chi-square test and OR index were used using SPSS software version 16. We have found that the IL23R reduced-function allele 1142A and genotypes CC and TC were overrepresented, especially in the Pad subgroup compared with the control group (44% versus 42%, 21% versus 22%, and 44% versus 39%, respectively. Increased risks of TB with minimal/moderate lung involvement, respectively. Our results demonstrate that the reduced-function polymorphism 1142G ¡ A encoded by IL23R influences the outcome of disease severity of active pulmonary TB in ZABOL patients. The genotypic and allelic frequency of IL23R 1142 G/A, and GM-CSF 3928 C/T (Ile117Thr) polymorphism in patients with tuberculosis was significantly different from the control group and this polymorphism was associated with the incidence of tuberculosis in the population of Sistan.
Case Study
Medical
Mohammad Reza Mohammadi; Mahram Ali Mehran; Amir Hossein Omidi; Mohammad Hadi Hassani
Abstract
Tuberculosis is a contagious infectious disease. This disease is called tuberculosis and is abbreviated as TB. Tuberculosis is one of the most important infectious diseases of this century, which can involve all the organs of the body, but the lungs are most affected by tuberculosis. The occurrence of ...
Read More
Tuberculosis is a contagious infectious disease. This disease is called tuberculosis and is abbreviated as TB. Tuberculosis is one of the most important infectious diseases of this century, which can involve all the organs of the body, but the lungs are most affected by tuberculosis. The occurrence of 10 million new cases of tuberculosis and the treatment of only two-thirds of them, which unfortunately was incomplete in more than 50% of cases, shows the depth of the disaster in these years. The occurrence of three epidemics of this disease in the last two decades shows that the prospect of controlling tuberculosis soon is very uncertain. Today, more than 8 million people are infected with this disease in the world every year, and until now, one-third of the world's people have been infected with the germ of tuberculosis without feeling sick. Tuberculous peritonitis is an uncommon disorder; sometimes, it is not considered in the initial evaluation of ascites. A negative 5-TU PPD test, or a low level of ascitic fluid protein, can mistakenly divert attention from tuberculosis. Tuberculosis peritonitis can be fatal if not diagnosed in time. Here we report a 67-year-old patient who was confirmed to have tuberculous peritonitis after clinical examination and laboratory diagnosis. The patient recovered after diagnosis with prescribed drugs.
Original Article
Medical
Paspula Soumya; Thurupu Sai Priya; Hameed Alla Qureshi; Alisha Firdous
Abstract
Cirrhosis is a late-stage liver disease in which/ advanced stage of scaring and conditions, such as hepatitis and chronic alcoholism. This disease is a condition in which your liver is scarred and permanently damaged. Scar tissue replaces healthy liver tissue and prevents your liver from working normally. ...
Read More
Cirrhosis is a late-stage liver disease in which/ advanced stage of scaring and conditions, such as hepatitis and chronic alcoholism. This disease is a condition in which your liver is scarred and permanently damaged. Scar tissue replaces healthy liver tissue and prevents your liver from working normally. Irreversible change in the normal liver tissue results in the degeneration of functioning liver cells and their replacement with fibrous connective tissue. In the present study, the risk assessment in alcoholic patients is assessed using laboratory data. Other biochemical parameters and severity are assessed using the child-pugh score. In the present study, 98 patients were identified of which 8 patients were excluded due to various reasons, and 90 patients’ data were analyzed. In order to assess the risk of cirrhosis in alcoholic patients, we used the cpugh score for assessing the severity and survival rate of subjects. A total of 90 patients were enrolled in this observational study. The study confirmed that more than 60 % of the subjects possess a severe risk of cirrhosis and risk factors such as age, gender, ALD, high BMI, social history family history, and encephalopathy.
Original Article
Bioinformatics
Redha Alwan Hasan Alhashimi; Ali Reza Mirzaei; Hasan Kamel Alsaedy
Abstract
Gastric cancer is the abnormal growth of stomach cells. The symptoms of this disease include difficulty in swallowing, heartburn, stomach pain, indigestion, nausea, vomiting, and blood in the stool. Gastric cancer is a multifactorial and genetic disease, and many genes and factors are involved in it. ...
Read More
Gastric cancer is the abnormal growth of stomach cells. The symptoms of this disease include difficulty in swallowing, heartburn, stomach pain, indigestion, nausea, vomiting, and blood in the stool. Gastric cancer is a multifactorial and genetic disease, and many genes and factors are involved in it. DCC and CDH1 are the genes silenced by hypermethylation in gastric cancer and play an influential role in suppressing gastric cancer tumors. The aim of this study was bioinformatics analysis at the genome and proteome level and evaluation and comparison of the expression of DCC and CDH1 genes in different human body tissues. The results of this study showed that the CDH1 gene is more expressed in the thyroid gland and Parathyroid gland and the DCC gene is more expressed in the testis, hippocampal formation, basal ganglia, midbrain, cerebral cortex, and hypothalamus. The expression analysis of these genes showed that both genes generally are more active in glands and have little expression in other body organs. Cellular analysis of DCC and CDH1 genes by antibodies that bind to the proteins of the target genes showed that both genes are active in the Golgi apparatus, with the difference that the DCC gene is more present in the nucleus and the CDH1 gene is more present in the plasma membrane. The expression level of the CDH1 gene is relatively higher than that of the DCC gene. Also, phenotypic studies of the DCC gene showed that this gene is related to colorectal cancer, and it was found that the CDH1 gene is effective in Blepharocheilodontic syndrome 1. Finally, considering the role of CDH1 and DCC genes as tumor suppressor genes, these items can be used for targeted treatments in gastric cancer.
)
)
)
)
)
)