%PDF-1.5
%
2 0 obj
<<
/Lang (en-US)
/MarkInfo <<
/Marked true
>>
/Metadata 4 0 R
/Pages 5 0 R
/StructTreeRoot 6 0 R
/Type /Catalog
>>
endobj
4 0 obj
<<
/Length 5574
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
Research progress on therapeutic effect and mechanism of hydrocortisone on sepsis
Yicen Long1
Xiaoqiang Du1
Zhi Ouyang1
Jian Zhong1
Zeng Ye1
*
Sepsis has remained a high mortality rate worldwide. Endothelial cell dysfunction is closely associated with the development of sepsis. Hydrocortisone has potent immunological and antitoxic effects, and thus it is frequently used in the treatment of septic shock. However, it can also cause respiratory damage and death by anaphylaxis. In recent years, the combination of hydrocortisone and other drugs such as vitamin C and thiamine has achieved promising outcomes in refractory septic shock. The present review focuses on the therapeutic effects of hydrocortisone in sepsis and summarizes the mechanisms by which hydrocortisone acted on the vascular endothelial cells. We highlighted the effect of hydrocortisone on anti-inflammation, anti-apoptosis, improvement of vascular functions, and anti-oxidative stress. We also pointed out that the mechanisms by which the combination therapy with other drugs enhances the effects of hydrocortisone are still unclear and need to be clarified to determine the benefit of the treatment of sepsis.
Hydrocortisone
Sepsis
Vascular Endothelial Cells
Inflammation
Apoptosis
Oxidative Stress
https://doi.org/10.55705/cmbr.2023.377524.1090
2023-08-25T07:54:25+03:30
Microsoft® Word 2013
Yicen Long1, Xiaoqiang Du1, Zhi Ouyang1, Jian Zhong1, Zeng Ye1,*
1Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China
2023-08-25T07:55:21+03:30
Microsoft® Word 2013
Hydrocortisone, Sepsis, Vascular Endothelial Cells, Inflammation, Apoptosis, Oxidative Stress
uuid:a0e67fcb-28cc-4b1a-820d-43b899808675
uuid:b5ce5908-22be-4989-8e0d-b050f72755a9
https://www.cmbr-journal.com/article_165223.html
endstream
endobj
33 0 obj
<<
/Filter [/FlateDecode]
/Length 8458
>>
stream
x=ksU0_RG`rNQ.NbK\N\RL(^.(u?vfIrڝhݽ_lg'ϟnOޯO\Ǜ?_\o/{KY7_||7O<5ulޜ=}cFթyno>s6o>}vմ?6o~0OO|Iw/;@zo(yJ9NF $(͛+yʱˆifz|At
LiwҌP0#>cA;U\vƥ1{N6*OCaDthlO}F}>m?`fu'ZwJ6 ag͕^ޘn6w;k{X_[lGk5 $WߵGbu-V&3푁VB2[k6 D-௫NEL>ū-װn=,zD9^s_rPǸagcKf+):'D@JS4-#Luy
N ]{q5tryUN4 o^푶~zF*3e#k3nԟT5/E
Щ44+SQx"P1Dt2H()<ߘ%0r(!`;#LJ}OhtgxՆۺyM[29ZYF0^ρ)@)=G}ur^wNZ&AEIһ