Document Type : Review Article

Authors

Department of Biology, Payame Noor University (PNU), P.Obox, 19395-4697 Tehran, Iran

Abstract

Diabetes, a chronic metabolic disease, is recognized as the most frequent disorder in the endocrine system with hyperglycemia dealing with either insulin resistance or insufficiency or both. This disease is usually associated with numerous acute and chronic complications. Also, the treatment of diabetes complications has imposed a heavy financial burden on most societies. During the last decade, pancreatic islet transplantation has been widely studied as a potential therapy for diabetes. Of course, due to its limitations removing pancreatic cells from the corpse is very difficult. Stem cells are renewable cellular sources that are proposed as a substitute for organ transplantation. These cells which can be found in almost all multicellular organisms are capable of division and transforming into highly specialized cells, they can also replace injured and lost cells. The possibility of using stem cells in diabetes therapy and building insulin-producing islets has long been considered by most scientists and can be a future hope for controlling diabetes. Interestingly, human stem cells derived from hematopoietic organs, liver, pancreas, and embryonic human stem cells are among these factors. In this article, a series of studies carried out on this field is briefly reviewed.

Graphical Abstract

The capacity of stem cells in treatment of diabetes

Keywords

Main Subjects

Selected author of this article by journal

Dr. Farzaneh Fazeli
Payame Noor University
Google Scholar

Open Access

This article is licensed under a CC BY License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit: http://creativecommons.org/licenses/by/4.0/

 

Publisher’s Note

CMBR journal remains neutral with regard to jurisdictional claims in published maps and institutional afflictions.

 

Letters to Editor

Given that CMBR Journal's policy in accepting articles will be strict and will do its best to ensure that in addition to having the highest quality published articles, the published articles should have the least similarity (maximum 15%). Also, all the figures and tables in the article must be original and the copyright permission of images must be prepared by authors. However, some articles may have flaws and have passed the journal filter, which dear authors may find fault with. Therefore, the editor of the journal asks the authors, if they see an error in the published articles of the journal, to email the article information along with the documents to the journal office.

CMBR Journal welcomes letters to the editor ([email protected], [email protected]) for the post-publication discussions and corrections which allows debate post publication on its site, through the Letters to Editor. Critical letters can be sent to the journal editor as soon as the article is online. Following points are to be considering before sending the letters (comments) to the editor.

[1] Letters that include statements of statistics, facts, research, or theories should include appropriate references, although more than three are discouraged.

[2] Letters that are personal attacks on an author rather than thoughtful criticism of the author’s ideas will not be considered for publication.

[3] There is no limit to the number of words in a letter.

[4] Letter writers should include a statement at the beginning of the letter stating that it is being submitted either for publication or not.

[5] Anonymous letters will not be considered.

[6] Letter writers must include Name, Email Address, Affiliation, mobile phone number, and Comments.

[7] Letters will be answered as soon as possible.

  1. Jerreat L (2009) Treatment of hyperglycaemia in patients with type 2 diabetes. Nursing standard (Royal College of Nursing (Great Britain) : 1987) 24 (1): 50-57; quiz 58, 60. doi:https://doi.org/10.7748/ns2009.09.24.1.58.c7262
  2. Olfatifar M, Karami M, Hosseini S Prevalence of Chronic Complications and Related Risk Factors of Diabetes in Patients Referred to the Diabetes Center of Hamedan Province. Sci J Hamadan Nurs Midwifery Fac 25 (2): 69-74
  3. Izadi N, Rahimi M, Rezvanmadani F, Shetabi H, Darbandi M (2017) A Survey on Epidemiology of Type II Diabetes in Patients Referring to the Diabetes Clinic in Kermanshah Province du ring 2013-14: A Short Report. Journal of Rafsanjan University of Medical Sciences 16 (1): 83-90
  4. Corriere M, Rooparinesingh N, Kalyani RR (2013) Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden. Current diabetes reports 13 (6): 805-813. doi:https://doi.org/10.1007/s11892-013-0425-5
  5. Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC (2004) Insulin secretion in type 1 diabetes. Diabetes 53 (2): 426-433. doi:https://doi.org/10.2337/diabetes.53.2.426
  6. Singh A, Verma V, Kumar M, Kumar A, Sarma DK, Singh B, Jha R (2022) Stem cells-derived in vitro meat: from petri dish to dinner plate. Critical Reviews in Food Science and Nutrition 62 (10): 2641-2654. doi:https://doi.org/10.1080/10408398.2020.1856036
  7. Buades JM, Craver L, Del Pino MD, Prieto-Velasco M, Ruiz JC, Salgueira M, de Sequera P, Vega N (2021) Management of Kidney Failure in Patients with Diabetes Mellitus: What Are the Best Options? Journal of Clinical Medicine 10 (13): 2943. doi:https://doi.org/10.3390/jcm10132943
  8. Nussbaum EL, Houghton P, Anthony J, Rennie S, Shay BL, Hoens AM (2017) Neuromuscular Electrical Stimulation for Treatment of Muscle Impairment: Critical Review and Recommendations for Clinical Practice. Physiotherapy Canada Physiotherapie Canada 69 (5): 1-76. doi:https://doi.org/10.3138%2Fptc.2015-88
  9. Lindberg I, Torbjørnsen A, Söderberg S, Ribu L (2017) Telemonitoring and Health Counseling for Self-Management Support of Patients With Type 2 Diabetes: A Randomized Controlled Trial. JMIR diabetes 2 (1): e10. doi:https://doi.org/10.2196/diabetes.6884
  10. Hosianpour F, Tehrani AM, Dehkordi AH, Ghaderi H (2021) Quality of life and its related factors among participants in Shahrecord–Iran cohort study. Przeglad Epidemiologiczny 75 (2): 248-253. doi:https://doi.org/10.32394/pe.75.14
  11. Nikpouraghdam M, Farahani AJ, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, Sepandi M, Jafari NJ, Izadi M, Qazvini A (2020) Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. Journal of Clinical Virology 127): 104378. doi:https://doi.org/10.1016/j.jcv.2020.104378
  12. Kabir MA, Kamrul-Hasan A, Faruque MO, Hoque F, Selim S, Abul M, Hasanat MF (2019) Frequency and predictors of hyperglycemia in patients with various thyroid disorders attending a tertiary hospital of Bangladesh. Sri Lanka Journal of Diabetes Endocrinology and Metabolism 9 (1): 18-25. doi:http://doi.org/10.4038/sjdem.v9i1.7366
  13. Kobrin Klein BE (2007) Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic epidemiology 14 (4): 179-183. doi:https://doi.org/10.1080/09286580701396720
  14. Eckert A, Galler A, Papsch M, Hess M, Holder M, Döing C, Bierkamp‐Christophersen D, Hammer E, Pappa A, Lanzinger S (2021) Are psychiatric disorders associated with thyroid hormone therapy in adolescents and young adults with type 1 diabetes? Journal of Diabetes 13 (7): 562-571. doi:https://doi.org/10.1111/1753-0407.13145
  15. Argyropoulos AJ, Robichaud P, Balimunkwe RM, Fisher GJ, Hammerberg C, Yan Y, Quan T (2016) Alterations of dermal connective tissue collagen in diabetes: molecular basis of aged-appearing skin. PloS one 11 (4): e0153806. doi:https://doi.org/10.1371/journal.pone.0153806
  16. Rahmani M, Raiszadeh F, Allahverdian S, Kiaii S, Navab M, Azizi F (2002) Coronary artery disease is associated with the ratio of apolipoprotein AI/B and serum concentration of apolipoprotein B, but not with paraoxonase enzyme activity in Iranian subjects. Atherosclerosis 162 (2): 381-389. doi:https://doi.org/10.1016/S0021-9150(01)00715-8
  17. Hua R, Li Y, Li W, Wei Z, Yuan Z, Zhou J (2021) Apolipoprotein B/A1 Ratio Is Associated with Severity of Coronary Artery Stenosis in CAD Patients but Not in Non-CAD Patients Undergoing Percutaneous Coronary Intervention. Disease markers 2021): 8959019. doi:https://doi.org/10.1155/2021/8959019
  18. Elahi-Moghaddam Z, Behnam-Rassouli M, Mahdavi-Shahri N, Hajinejad-Boshroue R, Khajouee E (2013) Comparative study on the effects of type 1 and type 2 diabetes on structural changes and hormonal output of the adrenal cortex in male Wistar rats. Journal of diabetes and metabolic disorders 12 (1): 9. doi:https://doi.org/10.1186%2F2251-6581-12-9
  19. Amini A, Chien S, Bayat M (2022) Potential of stem cells for treating infected Diabetic Foot Wounds and Ulcers: a systematic review. Mol Biol Rep). doi:https://doi.org/10.1007/s11033-022-07721-6
  20. Wan J, Xia L, Liang W, Liu Y, Cai Q (2013) Transplantation of bone marrow-derived mesenchymal stem cells promotes delayed wound healing in diabetic rats. Journal of diabetes research 2013): Article ID: 647107. doi:https://doi.org/10.1155/2013/647107
  21. Chrvala CA, Sherr D, Lipman RD (2016) Diabetes self-management education for adults with type 2 diabetes mellitus: A systematic review of the effect on glycemic control. Patient education and counseling 99 (6): 926-943. doi:https://doi.org/10.1016/j.pec.2015.11.003
  22. Lehmann R (2018) Beta-cell replacement for treatment of severe hypoglycemia: long-term comparison between islet-kidney vs. pancreas-kidney transplantation. Diabetologia Hungarica 26): 207-220. doi:https://doi.org/10.24121/dh.2018.11
  23. Gerber P, Pavlicek V, Demartines N, Zuellig R, Pfammatter T, Wüthrich R, Weber M, Spinas G, Lehmann R (2008) Simultaneous islet–kidney vs pancreas–kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up. Diabetologia 51 (1): 110-119. doi:https://doi.org/10.1007/s00125-007-0860-4
  24. Lee S-H, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P (2009) Human β-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies. Transplantation 87 (7): 983. doi:https://doi.org/10.1097%2FTP.0b013e31819c86ea
  25. Simerman AA, Dumesic DA, Chazenbalk GD (2014) Pluripotent muse cells derived from human adipose tissue: a new perspective on regenerative medicine and cell therapy. Clinical and Translational Medicine 3 (1): 1-8. doi:https://doi.org/10.1186/2001-1326-3-12
  26. Daniels JT, Dart JK, Tuft SJ, Khaw PT (2001) Corneal stem cells in review. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 9 (6): 483-494. doi:https://doi.org/10.1046/j.1524-475x.2001.00483.x
  27. Jose J, George T, Thomas AM (2020) Regulation of stem cell-based research in India in comparison with the US, EU and other Asian countries: current issues and future perspectives. Current Stem Cell Research & Therapy 15 (6): 492-508. doi:https://doi.org/10.2174/1574888X15666200402134750
  28. Zhao Y, Wang H, Mazzone T (2006) Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Experimental cell research 312 (13): 2454-2464. doi:https://doi.org/10.1016/j.yexcr.2006.04.008
  29. Secco M, Zucconi E, Vieira NM, Fogaça LL, Cerqueira A, Carvalho MDF, Jazedje T, Okamoto OK, Muotri AR, Zatz M (2008) Mesenchymal stem cells from umbilical cord: do not discard the cord! Neuromuscular Disorders 18 (1): 17-18. doi:https://doi.org/10.1016/j.nmd.2007.11.003
  30. Schütt J, Nägler T, Schenk T, Brioli A (2021) Investigating the Interplay between Myeloma Cells and Bone Marrow Stromal Cells in the Development of Drug Resistance: Dissecting the Role of Epigenetic Modifications. Cancers 13 (16): 4069. doi:https://doi.org/10.3390/cancers13164069
  31. Broccaioli E, Niada S, Rasperini G, Ferreira LM, Arrigoni E, Yenagi V, Brini AT (2013) Mesenchymal Stem Cells from Bichat's Fat Pad: In Vitro Comparison with Adipose-Derived Stem Cells from Subcutaneous Tissue. BioResearch open access 2 (2): 107-117. doi:https://doi.org/10.1089%2Fbiores.2012.0291
  32. Wang H, Yang Y, Liu J, Qian L (2021) Direct cell reprogramming: approaches, mechanisms and progress. Nature Reviews Molecular Cell Biology 22 (6): 410-424. doi:https://doi.org/10.1038/s41580-021-00335-z
  33. Ieda M (2013) Direct reprogramming into desired cell types by defined factors. The Keio Journal of Medicine): 2012-0017-RE. doi:https://doi.org/10.2302/kjm.2012-0017-RE
  34. Sachamitr P, Hackett S, Fairchild PJ (2014) Induced pluripotent stem cells: challenges and opportunities for cancer immunotherapy. Frontiers in immunology 5): 176. doi:https://doi.org/10.3389/fimmu.2014.00176/full
  35. Zahiri M, Shafikhodaii S, Keshavarz H (2014) Stem cells in review. ISMJ 17 (4): 733-747. doi:PMID: 27737521; PMCID: PMC5152786
  36. Akbari A, Jabbari N, Sharifi R, Ahmadi M, Vahhabi A, Seyedzadeh SJ, Nawaz M, Szafert S, Mahmoodi M, Jabbari E (2020) Free and hydrogel encapsulated exosome-based therapies in regenerative medicine. Life sciences 249): 117447. doi:https://doi.org/10.1016/j.lfs.2020.117447
  37. Ebrahimi A, Ahmadi H, Pourfraidon Ghasrodashti Z, Tanide N, Shahriarirad R, Erfani A, Ranjbar K, Ashkani-Esfahani S (2021) Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review. Bosnian journal of basic medical sciences 21 (6): 672-701. doi:https://doi.org/10.17305/bjbms.2021.5508
  38. Larijani B, Akrami S, Amoli M (2005) Insulin production by human stem cells. Iranian Journal of Endocrinology and Metabolism 7 (3): 269-278
  39. Li TD, Feng GH, Li YF, Wang M, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q (2017) Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A 114 (45): 11974-11979. doi:https://doi.org/10.1073/pnas.1708710114
  40. Burns CJ, Persaud SJ, Jones PM (2004) Stem cell therapy for diabetes: do we need to make beta cells? Journal of endocrinology 183 (3): 437-443. doi:https://doi.org/10.1677/joe.1.05981
  41. Meier JJ, Bhushan A, Butler PC (2006) The potential for stem cell therapy in diabetes. Pediatric Research 59 (4): 65-73. doi:https://doi.org/10.1203/01.pdr.0000206857.38581.49
  42. Zeeshan N, Naveed M, Irshad DFA, Ahsan A, Abrar M, Ghafoor S (2017) Journal of Cell Science & Therapy. Journal of Cell Science & Therapy 8 (2): 1000263. doi:https://doi.org/10.4172/2157-7013.100026
  43. Rahim F, Arjmand B, Shirbandi K, Payab M, Larijani B (2018) Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits. Stem cell investigation 5): 40. doi:https://doi.org/10.21037%2Fsci.2018.11.01
  44. Lopes L, Setia O, Aurshina A, Liu S, Hu H, Isaji T, Liu H, Wang T, Ono S, Guo X (2018) Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research. Stem cell research & therapy 9 (1): 1-16. doi:https://doi.org/10.1186/s13287-018-0938-6
  45. Mathias E, Goveas R, Rajak M (2018) Stem cell therapy: recent success and continuing progress in treating diabetes. Int J Stem Cell Res Ther 5 (1): 1-8. doi:https://doi.org/10.23937/2469-570X/1410053
  46. Ferguson AM, Rubin MA (2022) Lineage plasticity in prostate cancer: Looking beyond intrinsic alterations. Cancer letters 548): 215901. doi:https://doi.org/10.1016/j.canlet.2022.215901
  47. Azizi R, Goodarzi MT, Salemi Z (2014) Effect of biochanin a on serum visfatin level of streptozocin-induced diabetic rats. Iranian Red Crescent medical journal 16 (9). doi:https://doi.org/10.5812%2Fircmj.15424
  48. Yu VW, Scadden DT (2016) Hematopoietic Stem Cell and Its Bone Marrow Niche. Current topics in developmental biology 118): 21-44. doi:https://doi.org/10.1016/bs.ctdb.2016.01.009
  49. Kim HS, Lee MK (2016) β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas. Journal of diabetes investigation 7 (3): 286-296. doi:https://doi.org/10.1111/jdi.12475
  50. Jung JA, Yoon YD, Lee HW, Kang SR, Han SK (2018) Comparison of human umbilical cord blood‐derived mesenchymal stem cells with healthy fibroblasts on wound‐healing activity of diabetic fibroblasts. International Wound Journal 15 (1): 133-139. doi:https://doi.org/10.1111/iwj.12849
  51. Yang L, Li S, Hatch H, Ahrens K, Cornelius JG, Petersen BE, Peck AB (2002) In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proceedings of the National Academy of Sciences 99 (12): 8078-8083
  52. Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429 (6987): 41-46. doi:https://doi.org/10.1038/nature02520