Document Type : Original Article
Authors
- Leli Rezaie-Kahkhaie 1
- Khadije Saravani 2
- Khadije Rezaie-Keikhaie 3
- Seyed Esmaeil Azimi-Khatibani 4
- Abdul Hafiz Daman-Sooz 5
- Mehdi Afshari 6
- Atefeh kamali 7
1 Department of Internal Medicine, School of Medicine, Amir al momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
2 Forensic medicine and toxicology, Zabol University of medical sciences, Zabol, Iran.
3 Department of Obstetrics and Gynecology, Medical Faculty, Zabol University of Medical Sciences, Zabol, Iran
4 Department of Pathology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
5 Student Research Committee, zabol university of Medical Sciences, zabol, Iran
6 Social Medicine Department, Medical Facuty, Zabol University of Medical Sciences, Zabol, Iran
7 Department of Microbiology, Medical Faculty- Zabol University of Medical Sciences, Zabol, Iran
Abstract
Today, due to the increase in life expectancy in HIV-infected patients, the incidence of related diseases such as hepatitis B and C due to similarity in transmission routes has become a major concern of the health community. Therefore, this study was performed to determine the prevalence of hepatitis B among HIV + patients in Zabol. This descriptive cross-sectional study was performed on 37 HIV-infected patients in Zabol city (2021-2022). In the present study, HIV-infected patients were screened for hepatitis B by measuring serum levels of HBC Ab and HBs Ag. Finally, the data in SPSS V21 software were analyzed. In the present study, a total of 37 HIV-infected patients with a mean age of 40.81- 11.64 years were evaluated. The present study's prevalence of HIV and HCV co-infection was 21.6%. Also, 13.5% of HIV patients had HBV and HCV simultaneously. Examination of risk factors for viral hepatitis in HIV-infected patients showed that unprotected sex (100%), injecting drug use or IDU (87.5%), dental procedures (75%), history of imprisonment (62.5%) and tattooing (50.5%) were the most common factors in HIV patients. Family history of hepatitis B (12.5%), alcohol (12.5%), transfusion (12.5%) and cupping (25%) were among the lowest cases in these patients. the frequency of HBV infection and co-infection with HCV and HBV in HIV-positive patients were relatively high. Except for the history of tattoos, there is no significant relationship between other risk factors and hepatitis B among HIV-positive patients.
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Zabol University of Medical Sciences
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- Indolfi G, Easterbrook P, Dusheiko G, Siberry G, Chang M-H, Thorne C, Bulterys M, Chan P-L, El-Sayed MH, Giaquinto C (2019) Hepatitis B virus infection in children and adolescents. The Lancet Gastroenterology & Hepatology 4(6):466-476. doi:https://doi.org/10.1016/S2468-1253(19)30042-1
- Thitipatarakorn S, Chinbunchorn T, Peelay J, Seekaew P, Amatavete S, Sangsai M, Pankam T, Avihingsanon A, Avery M, Phanuphak P (2022) Prevalence and the associated factors of hepatitis B and hepatitis C viral infections among HIV-positive individuals in same-day antiretroviral therapy initiation program in Bangkok, Thailand. BMC Public Health 22(1):1-9. doi:https://doi.org/10.1186/s12889-021-12429-6
- Thio CL, Seaberg EC, Skolasky Jr R, Phair J, Visscher B, Muñoz A, Thomas DL (2002) HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). The Lancet 360(9349):1921-1926. doi:https://doi.org/10.1016/S0140-6736(02)11913-1
- Barin F (2022) HIV/AIDS as a model for emerging infectious disease: origin, dating and circumstances of an emblematic epidemiological success. La Presse Médicale):104128. doi:https://doi.org/10.1016/j.lpm.2022.104128
- Kenfack-Momo R, Kenmoe S, Takuissu GR, Ebogo-Belobo JT, Kengne-Ndé C, Mbaga DS, Tchatchouang S, Oyono MG, Kenfack-Zanguim J, Lontuo Fogang R (2022) Epidemiology of hepatitis B virus and/or hepatitis C virus infections among people living with human immunodeficiency virus in Africa: A systematic review and meta-analysis. PloS one 17(5):e0269250. doi:https://doi.org/10.1371/journal.pone.0269250
- Crowell TA, Gebo KA, Balagopal A, Fleishman JA, Agwu AL, Berry SA, Network HR (2014) Impact of hepatitis co-infection on hospitalization rates and causes in a multi-center cohort of persons living with HIV. Journal of acquired immune deficiency syndromes (1999) 65(4):429. doi:https://doi.org/10.1097%2FQAI.0000000000000059
- Matthews PC, Geretti AM, Goulder PJ, Klenerman P (2014) Epidemiology and impact of HIV coinfection with hepatitis B and hepatitis C viruses in Sub-Saharan Africa. Journal of clinical virology 61(1):20-33. doi:https://doi.org/10.1016/j.jcv.2014.05.018
- Liang X, Bi S, Yang W, Wang L, Cui G, Cui F, Zhang Y, Liu J, Gong X, Chen Y (2009) Epidemiological serosurvey of hepatitis B in China—declining HBV prevalence due to hepatitis B vaccination. Vaccine 27(47):6550-6557. doi:https://doi.org/10.1016/j.vaccine.2009.08.048
- Zhang L, Guo J, Duan K (2019) Comparative analysis of the safety and efficacy of HBsAg-1018 versus HBsAg-Eng: A meta-analysis. Central European Journal of Immunology 44(4):455-462. doi:https://doi.org/10.5114/ceji.2019.92808
- Wang H, Men P, Xiao Y, Gao P, Lv M, Yuan Q, Chen W, Bai S, Wu J (2019) Hepatitis B infection in the general population of China: a systematic review and meta-analysis. BMC infectious diseases 19(1):1-10. doi:https://doi.org/10.1186/s12879-019-4428-y
- Song C, Lv J, Liu Y, Chen JG, Ge Z, Zhu J, Dai J, Du L-B, Yu C, Guo Y (2019) Associations between hepatitis B virus infection and risk of all cancer types. JAMA network open 2(6):e195718-e195718. doi:https://doi.org/10.1001/jamanetworkopen.2019.5718
- Hui C, Nan L, Ji ZH, Pu ZS, Guo ZW, Jie G, Shao ZJ, Liu YW, Yan YP (2020) Assessment on the effects of hepatitis B prevention and control measures in western China: a comparison of three population-based serosurveys. Biomedical and Environmental Sciences 33(10):735-744. doi:https://doi.org/10.3967/bes2020.098
- Hou C, Hua Z, Xu P, Xu H, Wang Y, Liao J, Di B (2020) Estimating the prevalence of hepatitis B by wastewater-based epidemiology in 19 cities in China. Science of the Total Environment 740:139696. doi:https://doi.org/10.1016/j.scitotenv.2020.139696
- Ayana DA, Mulu A, Mihret A, Seyoum B, Aseffa A, Howe R (2020) Occult Hepatitis B virus infection among HIV negative and positive isolated anti-HBc individuals in eastern Ethiopia. Scientific reports 10(1):1-9. doi:https://doi.org/10.1038/s41598-020-79392-x
- Hamilton E, Yang L, Mentzer AJ, Guo Y, Chen Y, Lv J, Fletcher R, Wright N, Lin K, Walters R (2022) Conventional and genetic risk factors for chronic Hepatitis B virus infection in a community-based study of 0.5 million Chinese adults. Scientific reports 12(1):1-11. doi:https://doi.org/10.1038/s41598-022-16360-7
- Sun X, Zhu Y, Tang F, Deng X, Wang Z, Liu Y (2021) Analysis of epidemiological serosurvey of hepatitis B virus among people under 29 years of age in Jiangsu Province, China. Human vaccines & immunotherapeutics 17(10):3729-3734. doi:https://doi.org/10.1080/21645515.2021.1928461
- Miao Z, Zhang S, Ou X, Li S, Ma Z, Wang W, Peppelenbosch MP, Liu J, Pan Q (2020) Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection. The Journal of infectious diseases 221(10):1677-1687. doi:https://doi.org/10.1093/infdis/jiz633
- Dias J, Hengst J, Parrot T, Leeansyah E, Lunemann S, Malone DF, Hardtke S, Strauss O, Zimmer CL, Berglin L (2019) Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells. Journal of hepatology 71(2):301-312. doi:https://doi.org/10.1016/j.jhep.2019.04.009
- Dore GJ, Soriano V, Rockstroh J, Kupfer B, Tedaldi E, Peters L, Neuhaus J, Puoti M, Klein MB, Mocroft A (2010) Frequent hepatitis B virus (HBV) rebound among HIV–HBV coinfected patients following antiretroviral therapy interruption in the SMART study. AIDS (London, England) 24(6):857. doi:https://doi.org/10.1097%2FQAD.0b013e328334bddb
- Singh KP, Crane M, Audsley J, Lewin SR (2017) HIV-Hepatitis B virus co-infection: epidemiology, pathogenesis and treatment. AIDS (London, England) 31(15):2035. doi:https://doi.org/10.1097%2FQAD.0000000000001574
- Leumi S, Bigna JJ, Amougou MA, Ngouo A, Nyaga UF, Noubiap JJ (2020) Global burden of hepatitis B infection in people living with human immunodeficiency virus: a systematic review and meta-analysis. Clinical infectious diseases 71(11):2799-2806. doi:https://doi.org/10.1093/cid/ciz1170
- Kafeero HM, Ndagire D, Ocama P, Walusansa A, Sendagire H (2020) Sero-prevalence of human immunodeficiency virus–hepatitis B virus (HIV–HBV) co-infection among pregnant women attending antenatal care (ANC) in sub-Saharan Africa (SSA) and the associated risk factors: a systematic review and meta-analysis. Virology journal 17(1):1-19. doi:https://doi.org/10.1186/s12985-020-01443-6
- Ataei B, Tayeri K, Kassaian N, Farajzadegan Z, Babak A (2010) Hepatitis B and C among patients infected with human immunodeficiency virus in Isfahan, Iran: seroprevalence and associated factors. Hepatitis monthly 10(3):188. doi:PMCID: PMC3269083; PMID: 22308138
- Nokhodian Z, Meshkati M, Adibi P, Ataei B, Kassaian N, Yaran M, Shoaei P, Hassannejad R (2012) Hepatitis C among intravenous drug users in Isfahan, Iran: a study of seroprevalence and risk factors. International journal of preventive medicine 3(Suppl1):S131. doi:PMCID: PMC3399288; PMID: 22826755
- Tien PC (2005) Management and Treatment of Hepatitis C Virus Infection in HIV-Infected Adults: Recommendations from the Veterans Affairs Hepatitis C Resource Center Program and National Hepatitis C Program Office: 1. Official journal of the American College of Gastroenterology| ACG 100(10):2338-2354
- Alavi SM, Etemadi A (2007) HIV/HBV, HIV/HCV and HIV/HTLV-1 co infection among injecting drug user patients hospitalized at the infectious disease ward of a training hospital in Iran. PAKISTAN JOURNAL OF MEDICAL SCIENCES 23(4):510-513
- Ejele O, Nwauche C, Erhabor O (2004) The prevalence of hepatitis B surface antigenaemia in HIV positive patients in the Niger Delta Nigeria. Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria 13(2):175-179. doi:PMID: 15293840
- Yang H, Li X, Stanton B, Liu H, Liu H, Wang N, Fang X, Lin D, Chen X (2005) Heterosexual transmission of HIV in China: a systematic review of behavioral studies in the past two decades. Sexually transmitted diseases 32(5):270. doi:https://doi.org/10.1097%2F01.olq.0000162360.11910.5a
- Li X, Stanton B, Fang X, Lin D, Mao R, Wang J, Cottrell L, Harris C (2004) HIV/STD risk behaviors and perceptions among rural-to-urban migrants in China. AIDS education and prevention: official publication of the International Society for AIDS Education 16(6):538. doi:https://doi.org/10.1521%2Faeap.16.6.538.53787
- Alam MM, Zaidi SZ, Malik SA, Shaukat S, Naeem A, Sharif S, Angez M, Butt JA (2007) Molecular epidemiology of Hepatitis B virus genotypes in Pakistan. BMC infectious diseases 7(1):1-6. doi:https://doi.org/10.1186/1471-2334-7-115
- Weng MK, Doshani M, Khan MA, Frey S, Ault K, Moore KL, Hall EW, Morgan RL, Campos‐Outcalt D, Wester C (2022) Universal hepatitis B vaccination in adults aged 19–59 years: Updated recommendations of the advisory committee on immunization practices—United States, 2022. American Journal of Transplantation 22(6):1714-1720. doi:https://doi.org/10.1111/ajt.16661
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