Global Sciences
Biosafety Society of IranCellular, Molecular and Biomedical Reports2823-25503120230301Comparative study on the efficacy of statin therapy in lowering cholesterol and assessing the risk of metabolic syndrome in patients under statins therapy1815846810.55705/cmbr.2022.361364.1064ENKodipelly RamanaRajuSmt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar, Telangana 509001, India0000-0002-0326-8542Afreen SharifaSmt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar, Telangana 509001, India0000-0002-6760-7005Paspula SoumyaSmt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar, Telangana 509001, India0000-0001-5034-6569Rumana KhanamSmt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar, Telangana 509001, India0000-0003-3702-1756Koyala Konda Banda SanjayBhargavSmt. Sarojini Ramulamma College of Pharmacy, Seshadrinagar, Mahabubnagar, Telangana 509001, India0000-0002-4210-177XJournal Article20220109The<strong> </strong>objective of the study is<strong> </strong>to compare and evaluate the efficacy of atorvastatin (group – A) versus rosuvastatin (group – B) on baseline parameters like lipid profile tests and to assess the risk of metabolic syndrome using a Mets calculator.<strong> </strong>A total of 100 patients were enclosed in the present study who met the inclusion criteria. They were divided into two groups based on their treatment plan Group A includes 24 males and 26 females while Group B includes 23 males and 27 females. The mean differences before treatment for group A and group B are as follows, HDL (31.52±0.35 and 28.34±0.480), LDL (161.4±1.09 and 163.16±0.94), Total cholesterol (252.82±1.09 and 255.56±1.26) and Triglycerides (214.2±0.86 and 215.98±0.62), VLDL (35.98±0.56 and 36.12±0.43). The mean differences after treatment for group A and group B are as follows HDL (39.92±0.46 and 42.04±0.30), LDL (144.96±0.68 and 138.34±0.73), Total cholesterol (181.48±1.98 vs 174.32±2.08), Triglycerides (185.94±1.22 vs 181.74±1.77), VLDL (27.14±0.21 and 24.72±0.27). Group B (P=0.001) exhibited a significantly greater reduction in cholesterol levels as compared to Group A (P = 0.002). The reductions in LDL, VLDL, Total Cholesterol, and Triglycerides along with increased HDL levels were found to be significantly more in the Rosuvastatin group. In this study, we observed that patients on Rosuvastatin exhibited better control over lipid profile when compared to patients who are on Atorvastatin. Since, this study was conducted on a smaller number of patients, to make consecutive remarks about the superiority of either of the treatment regimen; further analysis of clinical trials is required for appropriate selection of the best statin therapy. https://www.cmbr-journal.com/article_158468_4752d7cb3ab0eb1d193adc285d78f116.pdfGlobal Sciences
Biosafety Society of IranCellular, Molecular and Biomedical Reports2823-25503120230301Screening for some virulent factors among bacterial isolates from surfaces of hospital fomites and hands of healthcare workers91615847010.55705/cmbr.2022.355120.1054ENMusa YakubuTulaDepartment of Biological Science Technology, Federal Polytechnic Mubi, PMB 035 Mubi, Adamawa State, Nigeria0000-0001-8666-6839Joel FilgonaDepartment of Microbiology, Adamawa State University, Mubi, Adamawa State, Nigeria0000-0002-1980-9577Serah EroldKyautaDepartment of Biomedical and Pharmaceutical Technology, Federal Polytechnic Mubi, Adamawa State, NigeriaRichard ElishaDepartment of Biological Science Technology, Federal Polytechnic Mubi, PMB 035 Mubi, Adamawa State, NigeriaJournal Article20220308The ability of the bacterial isolate to cause debilitating effects on the host is intricate and is a function of many factors, particularly that of the host and the bacteria. Among the bacterial factors are the virulence mechanisms. As such this research was a cross-sectional study conducted between October–December 2021 to establish the existence of virulence determinants on bacterial isolates from hospital fomites and the hands of healthcare workers. To achieve this, 100 samples (including sink, beddings, door handles, benches, and hands of healthcare workers) from children, female and male wards of Mubi General Hospital were analyzed for bacterial growth and were identified by standard procedure. Isolates were subsequently screened for virulent determinants (hemolysis, hemagglutination, biofilm production, and heteroresistance) phenotypically by standard methods. From the 72 bacterial isolates recovered, 23(31.9%) were biofilm-producing organisms. Of these, 15(20.8%) and 8(11.1%) were moderate and high biofilm-producing organisms respectively with no statistical difference (P=0.665). <em>Pseudomonas</em> <em>aeruginosa</em> (13.9%) was the most predominant biofilm-producing organism. Furthermore, hemolysin production was predominant in <em>Staphylococcus aureus</em> (71.4%), while positive hemagglutination reaction was predominant in <em>P. aeruginosa</em> (38.5%). Sixteen (16) bacterial isolates showed heteroresistance (HR) to various antibiotics; of these, <em>Escherichia</em> <em>coli</em> (43.8%) constitute the majority of the isolates. The expression of such virulence determinants by bacterial isolates in the study area may constitute a health risk to patients and hamper the quality of health care delivery. https://www.cmbr-journal.com/article_158470_b53ecf2dc75765ea124c24ff00c4bfa0.pdfGlobal Sciences
Biosafety Society of IranCellular, Molecular and Biomedical Reports2823-25503120230301Support and control during childbirth and attachment after birth in mothers referring to comprehensive health centers in Bijar, 2019172816030210.55705/cmbr.2022.355559.1055ENHateme AlaviDepartment of Midwifery, Kurdistan University of Medical Sciences, Kurdistan, Sanandaj, Iran0000-0000-0000-0000Farzaneh ZaheriDepartment of Midwifery, Clinical Care Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Kurdistan, Sanandaj, Iran0000-0002-7827-8008Roonak ShahoeiDepartment of Midwifery, Clinical Care Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Kurdistan, Sanandaj, Iran0000-0002-5509-4257Journal Article20220410Childbirth is one of the most important experiences in the life of mothers, which can bring tensions and worries due to physical and psychological changes. Therefore, the present study was conducted to determine the amount of support and control during childbirth and attachment after birth in mothers who were referred to comprehensive health centers in Bijar County, in 2019. In this descriptive-analytical study, the studied population consisted of all the mothers who were referred to the comprehensive health centers of Bijar, who had passed 28 days after giving birth. The participants in the study were available to choose and completed the questionnaires for support and control during childbirth and attachment after birth. The collected data were analyzed using SPSS statistical software version 22 and multiple regression statistical tests, and a significance level of p<0.05 was considered. The results of the study showed that the level of support and control during childbirth was 83.32±17.038 and the level of attachment after birth was 47.70±4.688.<strong> </strong>Also, the results of the study showed that none of the investigated demographic variables were related to support and control during childbirth. The type of delivery (vaginal delivery with episiotomy r=-2.226, p=0.012) and the baby's gender (r=9.927, p=0.047) were related to support and control during delivery. Also, the results showed that among the demographic variables examined with attachment after birth, the variable of income (equal to monthly expenses r=6.307, p=0.01) had a positive and significant relationship with attachment after birth. The findings showed that support and control are at a moderate level and attachment after birth is at an average level, so it seems that with the necessary training on the importance of mother and child attachment to medical personnel, an effective step can be taken to improve these two factors and their consequences. https://www.cmbr-journal.com/article_160302_1cc762a8b170df2fa381b07b1f4ae64d.pdfGlobal Sciences
Biosafety Society of IranCellular, Molecular and Biomedical Reports2823-25503120230301Study of thyroid hormones effect on biochemical parameters of liver function in Iraqi patients293416094510.55705/cmbr.2022.365507.1072ENHuda KadhimJaaferDepartment of Chemistry, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkeyorg/0000-0002-0318-234Melike BilgiKamacDepartment of Chemistry, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkey0000-0002-3381-7522Abdulnasser MohammedAl-GeboriDepartment of Applied Science, University of Technology, Baghdad, Iraq0000-0002-7499-1180Journal Article20220413This study was aimed to study the effect of thyroid hormones on some biochemical tests of liver function in Iraqi male patients and to study the relationship between them. A controlled study included 135 samples from patients and controls, group B, 45 patients with a liver disorder, and group C: 45 patients with a thyroid disorder, and group A: 45 healthy people (as the controls group). The study concluded that there were significant statistically significant differences for patients with liver disease, as well as for patients who suffer from abnormalities in the functions of the thyroid gland. For triiodothyronine (T3) and thyroxine (T4), there was clear importance and a slight impact for patients with liver disease. Because of the defect in the liver enzymes, this led to an increase in the TSB percentage, which increased significantly. Alkaline and Albumin levels indicate statistical significance within the results of our study. Serum protein levels had no significant changes in our study. https://www.cmbr-journal.com/article_160945_5641db0f93c2d317915b15e4ec32f416.pdfGlobal Sciences
Biosafety Society of IranCellular, Molecular and Biomedical Reports2823-25503120230301Antibacterial silver nanoparticles: effects on bacterial nucleic acids354016030110.55705/cmbr.2022.361677.1065ENMehran AlaviDepartment of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, IranNanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, IranMichael R.HamblinDepartment of Dermatology, Harvard Medical School, Boston, MA 02115, USAWellman Center for Photomedicine, Massachusetts General Hospital, BAR414, 40 Blossom Street, Boston, MA 02114, USA0000-0001-6431-4605Journal Article20220311Various microorganisms are located on the human skin, mucous membrane and inside the human body. Many of these microorganisms are beneficial and few are even essential, however, some pathogens are known to cause infection and have the ability to attack and damage the host tissue. Treatment of infectious bacterial disease by antibiotics is one of the major conventional strategies. Gram-positive and Gram-negative bacteria have developed resistance to conventional antibiotics by various mechanisms, including overexpression of efflux pumps, preventing drug penetration into the cells, genetic mutations, increased production of competitive inhibitors of antibiotics, or overexpression of enzymes that inactivate or hydrolyze antibiotics. Consequently, finding a new approach to overcome these hindrances is vital for the treatment of severe bacterial infections. Nanomaterials can be effective therapeutic compounds, with unique properties compared to bulk materials. Metal and metal oxide nanoparticles, particularly silver nanoparticles, have demonstrated strong antibacterial activity against most (if not all) multidrug-resistant bacteria. Several antibacterial mechanisms have been proposed for these nanoparticles, however, their interaction with bacterial nucleic acids is not completely understood, so this review discusses recent advances in this area. https://www.cmbr-journal.com/article_160301_8e1f8423324b6e66bd8a532be0b6a1c0.pdfGlobal Sciences
Biosafety Society of IranCellular, Molecular and Biomedical Reports2823-25503120230301Available drug therapies on COVID-19 and its side effects: An overview416116094610.55705/cmbr.2022.364739.1071ENNamrata MalikDepartment of Life Sciences and Biotechnology, Chhatrapati Shivaji Maharaj University, Panvel, Navi Mumbai
Maharashtra 410206, India0000-0001-7765-2646Umesh PravinDhuldhajDepartment of Biotechnology, School of Life Sciences, Swami Ramanand Teerth Marathwada University, Nanded 431606, Maharashtra, India0000000274394669Journal Article20220507The sudden outbreak of coronavirus turned into a pandemic and resulted in huge socio-economic and human losses becoming a public health emergency. It took just 3-4 months to spread and encroach all over the world and not even a single country is left was unaffected by the coronavirus. WHO started clinical, epidemiological, and laboratory investigations in response to this outbreak to control the further spread of the virus. The coronaviruses are enveloped and pleomorphic. The spike proteins present on the virus surface mediate its entry into host cells. The vaccines recommended have been shown to reduce COVID-19 illness symptoms but somehow their role in the transmission of the disease is unclear. By contrast, immunomodulatory therapy has also benefitted patients. As long as SARS-CoV-2 spreads in the population there are chances of its mutation as RNA viruses mutate over time and its upcoming variants. The previous Delta variant and the latest Omicron variant may cause much more serious deaths and health issues. Variants reduce the effectiveness of monoclonal antibodies or antibodies generated by previously administered vaccines. This review focuses on the pathogenicity of coronavirus and various drug therapies available to date to cure the disease. The present study also highlights the target sites and side effects of available drugs for treating COVID-19. https://www.cmbr-journal.com/article_160946_db588ecfacd2fe991fa9d0cf181f9aa7.pdf