Cell, Organ and Tissue Culture
Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019

Afshin Fathi; Manouchehr Barak; Mahshid Damandan; Firouz Amani; Rouhallah Moradpour; Irada Khalilova; Mehdi Valizadeh

Volume 1, Issue 1 , April 2021, , Pages 1-6

https://doi.org/10.55705/cmbr.2021.138793.1000

Abstract
  Glucose-6-phosphate dehydrogenase (G6PD) is one of the most common genetic deficiencies that affect approximately 400 million people worldwide. This study aimed to identify neonates with G6PD deficiency in Ardabil province during 2017-2018. This cross-sectional study was conducted on all term and preterm ...  Read More

Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019


Phytochemistry and Biosynthesis
Nitric oxide signaling pathway in medicinal plants

Ali Salehi-Sardoei; Halimeh Khalili

Volume 2, Issue 1 , March 2022, , Pages 1-9

https://doi.org/10.55705/cmbr.2022.330292.1019

Abstract
  Nitrogen monoxide or nitric oxide is a biological active growth regulator that a wide range of studies have recently shown that it acts as a growth regulator (signaling molecule) in plants. As soon as Nitric Oxide (NO) known as a new biological agent in plants and animals, biological branches of sciences ...  Read More

Nitric oxide signaling pathway in medicinal plants


Medical
Comparative study on the efficacy of statin therapy in lowering cholesterol and assessing the risk of metabolic syndrome in patients under statins therapy

Kodipelly Ramana Raju; Afreen Sharifa; Paspula Soumya; Rumana Khanam; Koyala konda Banda Sanjay Bhargav

Volume 3, Issue 1 , March 2023, , Pages 1-8

https://doi.org/10.55705/cmbr.2022.361364.1064

Abstract
  The objective of the study is to compare and evaluate the efficacy of atorvastatin (group – A) versus rosuvastatin (group – B) on baseline parameters like lipid profile tests and to assess the risk of metabolic syndrome using a Mets calculator. A total of 100 patients were enclosed in the ...  Read More

Comparative study on the efficacy of statin therapy in lowering cholesterol and assessing the risk of metabolic syndrome in patients under statins therapy


DNA, RNA, protein components
Association between Human Endogenous Retrovirus K gene expression and breast cancer

Masoud Tourang; Le Fang; Yuan Zhong; Ram Chandra Suthar

Volume 1, Issue 1 , April 2021, , Pages 7-13

https://doi.org/10.55705/cmbr.2021.138810.1008

Abstract
  Breast cancer is one of the most common cancers known, and it is also a significant cause of death in women. If breast cancer is diagnosed in the early stages of the disease and treated appropriately, we can see an increase in life expectancy for more than 90% of patients. Research on molecular biomarkers ...  Read More

Association between Human Endogenous Retrovirus K gene expression and breast cancer


Medical
Screening for some virulent factors among bacterial isolates from surfaces of hospital fomites and hands of healthcare workers

Musa Yakubu Tula; Joel Filgona; Serah Erold Kyauta; Richard Elisha

Volume 3, Issue 1 , March 2023, , Pages 9-16

https://doi.org/10.55705/cmbr.2022.355120.1054

Abstract
  The ability of the bacterial isolate to cause debilitating effects on the host is intricate and is a function of many factors, particularly that of the host and the bacteria. Among the bacterial factors are the virulence mechanisms. As such this research was a cross-sectional study conducted between ...  Read More

Screening for some virulent factors among bacterial isolates from surfaces of hospital fomites and hands of healthcare workers


Nano-Biotechnology
The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action

Mehran Alavi; Mahendra Rai; Fleming Martinez; Danial Kahrizi; Haroon Khan; Irwin Rose Alencar de Menezes; Henrique Douglas Melo Coutinho; José Galberto Martins Costa

Volume 2, Issue 1 , March 2022, , Pages 10-21

https://doi.org/10.55705/cmbr.2022.147090.1023

Abstract
  The applications of nanoparticles in various practical fields, owing to their unique properties compared with bulk materials, have been occupying the minds of scientists for several decades. In this regard, a combination of pharmacology and nanotechnology has contributed to producing newer effective ...  Read More

The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action


Cell, Organ and Tissue Culture
Cytotoxic effect of diferuloylmethane, a derivative of turmeric on different human glioblastoma cell lines

Ismael Bilal; Sijia Xie; Muna S Elburki; Zahra Aziziaram; Sangar Muhammad Ahmed; Salah Tofik Jalal Balaky

Volume 1, Issue 1 , April 2021, , Pages 14-22

https://doi.org/10.55705/cmbr.2021.138815.1004

Abstract
  Glioblastoma is a fatal brain tumor, and the standard treatment for this cancer is the surgical removal of the tumor followed by chemotherapy with temozolomide and radiotherapy. Because chemotherapy has many side effects, the use of compounds extracted from natural herbs, due to fewer side effects, can ...  Read More

Cytotoxic effect of diferuloylmethane, a derivative of turmeric on different human glioblastoma cell lines


Medical
Support and control during childbirth and attachment after birth in mothers referring to comprehensive health centers in Bijar, 2019

Hateme Alavi; Farzaneh Zaheri; Roonak Shahoei

Volume 3, Issue 1 , March 2023, , Pages 17-28

https://doi.org/10.55705/cmbr.2022.355559.1055

Abstract
  Childbirth is one of the most important experiences in the life of mothers, which can bring tensions and worries due to physical and psychological changes. Therefore, the present study was conducted to determine the amount of support and control during childbirth and attachment after birth in mothers ...  Read More

Support and control during childbirth and attachment after birth in mothers referring to comprehensive health centers in Bijar, 2019


Genetic engineering
Therapeutic potential of Seabuckthorn (Hippophae rhamnoides L.) in medical sciences

Hamid Ahani; Soroush Attaran

Volume 2, Issue 1 , March 2022, , Pages 22-32

https://doi.org/10.55705/cmbr.2022.330326.1020

Abstract
  Seabuckthorn has multiple-use properties. This review explores the medicinal applications of Hippophae rhamnoides in healing ailments. The plant is being used in different parts of the world for its nutritional and medicinal properties. Sea buckthorn-based preparations have been extensively exploited ...  Read More

Therapeutic potential of Seabuckthorn (Hippophae rhamnoides L.) in medical sciences


Gene Expression Studies
Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue

Zahra Aziziaram; Ismael Bilal; Yuan Zhong; Azzadin Kamal Mahmod; Mohammad Reza Roshandel

Volume 1, Issue 1 , April 2021, , Pages 23-32

https://doi.org/10.55705/cmbr.2021.138879.1001

Abstract
  Naproxen is a common analgesic and antipyretic medication that is widely used around the world. This medicine at high doses leads to liver and kidney necrosis in humans and animals. The mechanism of kidney damage, unlike liver damage, is not well understood and is one of the most common causes of emergency ...  Read More

Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue


Biochemistry
Study of thyroid hormones effect on biochemical parameters of liver function in Iraqi patients

Huda Kadhim Jaafer; Melike Bilgi Kamac; Abdulnasser Mohammed Al-Gebori

Volume 3, Issue 1 , March 2023, , Pages 29-34

https://doi.org/10.55705/cmbr.2022.365507.1072

Abstract
  This study was aimed to study the effect of thyroid hormones on some biochemical tests of liver function in Iraqi male patients and to study the relationship between them. A controlled study included 135 samples from patients and controls, group B, 45 patients with a liver disorder, and group C: 45 patients ...  Read More

Study of thyroid hormones effect on biochemical parameters of liver function in Iraqi patients


Gene Expression Studies
Relevance of genetic polymorphisms of the human cytochrome P450 3A4 in rivaroxaban-treated patients

Muhammed Furkan Ercisli; Gao Lechun; Sarhang Hasan Azeez; Rebwar Muhammad Hamasalih; Siyan Song; Zahra Aziziaram

Volume 1, Issue 1 , April 2021, , Pages 33-41

https://doi.org/10.55705/cmbr.2021.138880.1003

Abstract
  Rivaroxaban is an anticoagulant drug that prevents forming of blood clots. In addition, it can be administered to prevent and treat thrombotic diseases such as atrial fibrillation, cardiac arrhythmia, heart valve disease, orthopedic surgery, and thrombophilia to reduce the risk of thrombosis. Various ...  Read More

Relevance of genetic polymorphisms of the human cytochrome P450 3A4 in rivaroxaban-treated patients


Cell structural and functions
Cellular structure and molecular functions of plants, animals, bacteria, and viruses

Hamid kheyrodin; Raheba Jami; Fazal Ur Rehman

Volume 2, Issue 1 , March 2022, , Pages 33-41

https://doi.org/10.55705/cmbr.2022.330941.1021

Abstract
  Plant cells are the basic unit of life in organisms of the kingdom Plantae. These organisms as eukaryotic cells have a true nucleus along with particular structures called organelles that perform various functions.  The plant cell wall can provide a structural framework to support plant ...  Read More

Cellular structure and molecular functions of plants, animals, bacteria, and viruses


Nano-Biotechnology
Antibacterial silver nanoparticles: effects on bacterial nucleic acids

Mehran Alavi; Michael R. Hamblin

Volume 3, Issue 1 , March 2023, , Pages 35-40

https://doi.org/10.55705/cmbr.2022.361677.1065

Abstract
  Various microorganisms are located on the human skin, mucous membrane and inside the human body. Many of these microorganisms are beneficial and few are even essential, however, some pathogens are known to cause infection and have the ability to attack and damage the host tissue. Treatment of infectious ...  Read More

Antibacterial silver nanoparticles: effects on bacterial nucleic acids


Medical
Available drug therapies on COVID-19 and its side effects: An overview

Namrata Malik; Umesh Pravin Dhuldhaj

Volume 3, Issue 1 , March 2023, , Pages 41-61

https://doi.org/10.55705/cmbr.2022.364739.1071

Abstract
  The sudden outbreak of coronavirus turned into a pandemic and resulted in huge socio-economic and human losses becoming a public health emergency. It took just 3-4 months to spread and encroach all over the world and not even a single country is left was unaffected by the coronavirus. WHO started clinical, ...  Read More

Available drug therapies on COVID-19 and its side effects: An overview


Cell, Organ and Tissue Culture
Insulin-producing cells from bone marrow stem cells versus injectable insulin for the treatment of rats with type I diabetes

Sarhang Hasan Azeez; Sarwar Nawzad Jafar; Zahra Aziziaram; Le Fang; Ahang Hasan Mawlood; Muhammed Furkan Ercisli

Volume 1, Issue 1 , April 2021, , Pages 42-51

https://doi.org/10.55705/cmbr.2021.138888.1006

Abstract
  Recently, stem cells have been considered renewable cell sources in the treatment of diabetes and the development of insulin-producing cells. In this regard, the current study aimed to compare Insulin-producing cells from bone marrow stem cells with injectable insulin in rats with type I diabetes. For ...  Read More

Insulin-producing cells from bone marrow stem cells versus injectable insulin for the treatment of rats with type I diabetes


Gene Expression Studies
Molecular analysis of Bio-makers of Chloroquine resistance in Plasmodium falciparum Isolate from Gombe Local Government Area, Gombe State, Nigeria

Ismail Muhammad; Pukuma Micah Sale; Muhammad Khadija Salisu; Tanko Mahmoud Muhammad; Bala Abubakar; Augustine Linda Maidala; Enock Nuwanyada

Volume 2, Issue 1 , March 2022, , Pages 42-55

https://doi.org/10.55705/cmbr.2022.335753.1033

Abstract
  Chloroquine was one of the most cheapest and effective chemotherapeutic drugs for Plasmodium falciparum-malaria, but for a long, the drug has been officially withdrawn in almost all malaria-endemic countries including Nigeria, due to the development of resistance by the parasite. Withdrawal of the drug ...  Read More

Molecular analysis of Bio-makers of Chloroquine resistance in Plasmodium falciparum Isolate from Gombe Local Government Area, Gombe State, Nigeria


Nano-Biotechnology
Antisense RNA, the modified CRISPR-Cas9, and metal/metal oxide nanoparticles to inactivate pathogenic bacteria

Mehran Alavi; Mahendra Rai

Volume 1, Issue 2 , August 2021, , Pages 52-59

https://doi.org/10.55705/cmbr.2021.142436.1014

Abstract
  Finding efficient therapeutic strategies to fight antibiotic-resistant bacteria is a complicated affair specifically in the therapy of chronic bacterial infections related to hospital-acquired infections. Recently, three major antibacterial systems based on antisense RNA, CRISPR-Cas9, and metal/metal ...  Read More

Antisense RNA, the modified CRISPR-Cas9, and metal/metal oxide nanoparticles to inactivate pathogenic bacteria


Medical
Evaluation of Active Pulmonary Tuberculosis Among Women With Diabetes

Razieh Behzadmehr; Khadije Rezaie-Keikhaie

Volume 2, Issue 1 , March 2022, , Pages 56-63

https://doi.org/10.55705/cmbr.2022.336572.1036

Abstract
  Diabetes is one of the most common non-contagious diseases in the world. This disease is the fourth or fifth cause of death in most developed countries. The relationship between tuberculosis and diabetes had been introduced years ago and diabetes is considered a threatening factor in tuberculosis in ...  Read More

Evaluation of Active Pulmonary Tuberculosis Among Women With Diabetes


DNA, RNA, protein components
Evaluation of antibiotic resistance and prevalence of multi-antibiotic resistant genes among Acinetobacter baumannii strains isolated from patients admitted to al-yarmouk hospital

Zahraa Khudhair Abbas-Al-Khafaji; Qassim hassan Aubais-aljelehawy

Volume 1, Issue 2 , August 2021, , Pages 60-68

https://doi.org/10.55705/cmbr.2021.142761.1015

Abstract
  Emerging antibiotic resistance in microorganisms particularly multidrug-resistant strains among bacteria are increasing because of misusing antibiotics as well as evolution of antibiotic resistance mechanisms. In this regard, Acinetobacter baumannii is one of the six most common multidrug-resistant microorganisms ...  Read More

Evaluation of antibiotic resistance and prevalence of multi-antibiotic resistant genes among Acinetobacter baumannii strains isolated from patients admitted to al-yarmouk hospital


Bioinformatics
Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes

Ali Reza Mirzaei; Vida Shakoory-Moghadam

Volume 2, Issue 2 , June 2022, , Pages 64-73

https://doi.org/10.55705/cmbr.2022.336232.1035

Abstract
  Different groups of enzymes and regulatory elements are involved in the synthesis of Ribodioside A, which is one of the most important sweetening compounds in stevia. The UGT family (UDP-glycosyltransferase) is a group of regulatory genes that are very effective in converting steviol glycoside to Ribodioside ...  Read More

Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes


DNA, RNA, protein components
Overview of typing techniques as molecular epidemiology tools for bacterial characterization

Nasim Almasian-Tehrani; Masoud Alebouyeh; Shahnaz Armin; Neda Soleimani; Leila Azimi; Roozbeh Shaker-Darabad

Volume 1, Issue 2 , August 2021, , Pages 69-77

https://doi.org/10.55705/cmbr.2021.143413.1016

Abstract
  The main purpose of microbial typing is to evaluate the relationships between microbial isolates. Microbial typing can use for identifying the source of infection by detecting a clonal link between the strains. Moreover, it can analyze outbreaks, antimicrobial-resistant strains, and evaluate the effectiveness ...  Read More

Overview of typing techniques as molecular epidemiology tools for bacterial characterization


Medical
Effect of unripe fruit extract of Momordica charantia on total cholesterol, total triglyceride and blood lipoproteins in the blood of rats with hyperlipidemia

Mehdi Doosti-Moghaddam; Hamid Reza Miri; Arezou Ghahghaei; Mohammad Reza Hajinezhad; Hadi Saboori

Volume 2, Issue 2 , June 2022, , Pages 74-86

https://doi.org/10.55705/cmbr.2022.338806.1038

Abstract
  Hyperlipidemia is a major risk factor for the development of cardiovascular disease. In this study, the effects of an unripe fruit extract of Momordica charantia on total cholesterol, total triglyceride and lipoproteins in the blood of mice with hyperlipidemia were investigated. In this study, 28 adult ...  Read More

Effect of unripe fruit extract of Momordica charantia on total cholesterol, total triglyceride and blood lipoproteins in the blood of rats with hyperlipidemia


Gene Expression Studies
Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital

Qassim hassan Aubais aljelehawy; Layth Hussein Hadi Alshaibah; Zahraa Khudhair Abbas Al- Khafaji

Volume 1, Issue 2 , August 2021, , Pages 78-87

https://doi.org/10.55705/cmbr.2021.144995.1017

Abstract
  Staphylococcus aureus contains numerous surface proteins called microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) that mediate binding to host tissues and initiate colonization leading to infection. Virulence genes such as enzymes, toxins, adhesin proteins, cell surface proteins ...  Read More

Evaluation of virulence factors among Staphylococcus aureus strains isolated from patients with urinary tract infection in Al-Najaf Al-Ashraf teaching hospital


Nano-Biotechnology
Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products

Mehran Alavi; Michael R. Hamblin; M. R. Mozafari; Irwin Rose Alencar de Menezes; Henrique Douglas Melo Coutinho

Volume 2, Issue 2 , June 2022, , Pages 87-97

https://doi.org/10.55705/cmbr.2022.338888.1039

Abstract
  Bacterial infections can be caused by contamination of labile blood products with specific bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Hospital equipment, bio-protective equipment, delivery systems, and medical devices can be easily contaminated by microorganisms. Multidrug-resistant ...  Read More

Surface modification of SiO2 nanoparticles for bacterial decontaminations of blood products