TY - JOUR ID - 158477 TI - Investigating the structure and function of Long Non-Coding RNA (LncRNA) and its role in cancer JO - Cellular, Molecular and Biomedical Reports JA - CMBR LA - en SN - AU - Alsaedy, Hasan Kamel AU - Mirzaei, Ali Reza AU - Alhashimi, Redha Alwan Hasan AD - Department of Chemistry and Biochemistry, College of Medicine, Misan University, Amarah, Maysan, Iraq AD - Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran AD - Department of Medicine, College of Medicine, Misan University, Amarah, Maysan, Iraq Y1 - 2022 PY - 2022 VL - 2 IS - 4 SP - 245 EP - 253 KW - lncRNA KW - Molecular reactions KW - cancer KW - therapeutic target DO - 10.55705/cmbr.2022.360799.1062 N2 - Cancer is one of the most complex and common diseases affected by many factors. In recent years, many studies have been conducted on the genetic characteristics of cancer, among which we can mention lncRNA Long Non-Coding RNAs, which effectively eliminate cancer tumors. LncRNAs are non-coding protein transcripts with a length of more than 200 nucleotides that react with other molecules through their unique structure and affect many cellular processes and chemical reactions in this way; they act as tumor suppressors and oncogenes in tumorigenic responses. On the other hand, lncRNAs play an essential role in cell proliferation, apoptosis, regulation of gene expression at different epigenetic levels of transcription, post-transcription, and interaction of molecules with other vital factors such as DNA, proteins, and other RNAs. Some lncRNAs can react with enzymes that change the state of chromatin and increase the transcriptional activity of some genes or turn off another group of genes. Also, lncRNAs are present in essential processes such as directing ribonucleoprotein complexes, regulating alternating processing, and maintaining the state of multipotency. Examining the function of lncRNAs has greatly impacted the early diagnosis and treatment of cancer cells. This review closely examines recent research on the use of lncRNAs in progression as clinical biomarkers and promising therapeutic targets in cancer.   UR - https://www.cmbr-journal.com/article_158477.html L1 - https://www.cmbr-journal.com/article_158477_8e578f5984be19a1c120ac2c8bf25ec6.pdf ER -