Medical
Mohammed Shaker Al-Awady; Besma Mohammed Ali
Abstract
Diabetes mellitus is a group of metabolic diseases with high prevalence, mortality and morbidity characterized by prolonged high blood glucose concentrations resulting from defects in insulin secretion, insulin action, or both. This study aimed to assess the role of vitamin D supplementation in glycemic ...
Read More
Diabetes mellitus is a group of metabolic diseases with high prevalence, mortality and morbidity characterized by prolonged high blood glucose concentrations resulting from defects in insulin secretion, insulin action, or both. This study aimed to assess the role of vitamin D supplementation in glycemic control in uncontrolled type 1 diabetes with vitamin D deficiency. It is a prospective study between 1st of October 2022 to 31st of July 2023, where ninety patients (male: female ratio 1:1) with uncontrolled type 1 diabetes and vitamin D deficiency attended The Specialized Center for Endocrinology and Diabetes in Baghdad Government-Iraq, their ages between 5-18 years were followed for 10months to assess their Hemoglobin A1c (Hba1c) and serum calcium after correction of vitamin D level with therapeutic doses of vitamin D. The findings of the study had shown that 41.1% of the patients had vitamin D insufficiency and 58.9% with deficiency regardless sex and age. All the obese children and 66.4% of the overweight had vitamin D deficiency with significant correlation with BMI (P<0.001). The severity of vitamin D was also related to duration of disease diagnoses (P<0.001). Good glycemic control occurs in patients with vitamin D levels>50ng/ml (P<0.01). In 14.5% of the patients after 6 months, their vitamin D levels again became deficient, so re-check was needed after 6 months from the end of the loading therapy. Vitamin D deficiency among the patients of diabetes mellitus type 1 was high and was closely related to glycemic control. The level of vitamin D was negatively related to the body weight and the duration of the disease. Additionally, the findings of the study have demonstrated therapeutic dose of vitamin D has the potential to manage glucose levels.
Medical
Farzaneh Fazeli; Masumeh Ahanjan
Abstract
Diabetes, a chronic metabolic disease, is recognized as the most frequent disorder in the endocrine system with hyperglycemia dealing with either insulin resistance or insufficiency or both. This disease is usually associated with numerous acute and chronic complications. Also, the treatment of diabetes ...
Read More
Diabetes, a chronic metabolic disease, is recognized as the most frequent disorder in the endocrine system with hyperglycemia dealing with either insulin resistance or insufficiency or both. This disease is usually associated with numerous acute and chronic complications. Also, the treatment of diabetes complications has imposed a heavy financial burden on most societies. During the last decade, pancreatic islet transplantation has been widely studied as a potential therapy for diabetes. Of course, due to its limitations removing pancreatic cells from the corpse is very difficult. Stem cells are renewable cellular sources that are proposed as a substitute for organ transplantation. These cells which can be found in almost all multicellular organisms are capable of division and transforming into highly specialized cells, they can also replace injured and lost cells. The possibility of using stem cells in diabetes therapy and building insulin-producing islets has long been considered by most scientists and can be a future hope for controlling diabetes. Interestingly, human stem cells derived from hematopoietic organs, liver, pancreas, and embryonic human stem cells are among these factors. In this article, a series of studies carried out on this field is briefly reviewed.
Medical
Razieh Behzadmehr; Khadije Rezaie-Keikhaie
Abstract
Diabetes is one of the most common non-contagious diseases in the world. This disease is the fourth or fifth cause of death in most developed countries. The relationship between tuberculosis and diabetes had been introduced years ago and diabetes is considered a threatening factor in tuberculosis in ...
Read More
Diabetes is one of the most common non-contagious diseases in the world. This disease is the fourth or fifth cause of death in most developed countries. The relationship between tuberculosis and diabetes had been introduced years ago and diabetes is considered a threatening factor in tuberculosis in the research history. Not only tuberculosis is prevalent among diabetic persons, but also diabetes can affect the appearance of imaging of tuberculosis. This is a kind of analytic study, a case-control study, which was carried out between the years 2014 and 2015 in Zabol City. In this study, the radiographic findings from the patients suffering from pulmonary tuberculosis in diabetic patients and not diabetic patients are compared. These radiographic were handed to a radiologist and the radiologic findings of these graphs from the anatomic location (upper and lower half of the right and left bellows), Presence or absence of cavities, nodules, density and pleural involvement were recorded and compared with the diabetic and non-diabetic group. After gathering of the data using SPSS software, descriptive statistics were presented in the form of (frequency, percent) graphs and a chi-square test (p<0.05) was used to analyze and comparing of the results of diabetic and un-diabetic patients. The population of the study consisted of Chest radiographs for 124 TB patients which 61 (49.19 %) were suffering from diabetics. In this study, 45 (71.43%) non-diabetic and 42 (65.85%) diabetic patients were women (p=0.7). There were 12 diabetic TB patients (19.67%) and 3 non-diabetic- TB patients (4.76%) with the consolidation of middle part of left lung (p=0.01) and 8 (13.11%) diabetic TB and 1 (1.59%) non-diabetic TB with reticulonodular infiltration of lower part of left lung (p=0.02). There was no significant difference in the rest of the radiographic results. The findings of this study indicate that reticulonodular infiltration and consolidation of lower &middle parts of the lung in TB diabetic patients is more than in TB non-diabetic patients and diabetes can affect the findings of pulmonary tuberculosis radiography.
)
)