Bioinformatics
Identification of some Echinophora platyloba miRNAs using computational methods and the effect of these miRNAs in the expression of TLN2 and ZNF521 genes in different human body organs

Sahand Sasani; Sajad Rashidi Monfared; Ali Reza Mirzaei

Volume 4, Issue 1 , March 2024, , Pages 43-53

https://doi.org/10.55705/cmbr.2023.386145.1100

Abstract
  MicroRNAs (miRNAs) are small (~22 nucleotides) non-coding endogenous RNA molecules that negatively regulate gene expression at the post-transcriptional level by degrading the target protein-coding mRNA genes or suppressing translation in plants, which consequently participate in a variety of biological ...  Read More

Identification of some Echinophora platyloba miRNAs using computational methods and the effect of these miRNAs in the expression of TLN2 and ZNF521 genes in different human body organs


Medical
Investigation of GJB2 and SLC26A4 genes related to pendred syndrome genetic deafness patients

Haider Majid Haider Al-Zaidi; Fatemehsadat Mousavinasab; Nika Radseresht; Ali Reza Mirzaei; Yasaman Moradi; Mohammad Mahmoudifar

Volume 3, Issue 3 , September 2023, , Pages 163-171

https://doi.org/10.55705/cmbr.2023.379262.1093

Abstract
  Deafness can occur due to damage to the ear, especially the inner ear. In other cases, the cause is a heterogeneous genetic abnormality and is caused by the changes that occur in the genes involved in the hearing process. Mutations in GJB2 and SLC26A4 genes are one of the most important causes of deafness ...  Read More

Investigation of GJB2 and SLC26A4 genes related to pendred syndrome genetic deafness patients


Medical
Comprehensive analysis of microRNA (miRNA) in cancer cells

Naghmana Kanwal; Othman Rashid Al Samarrai; Haider Majid Haider Al-Zaidi; Ali Reza Mirzaei; Mohammad Javad Heidari

Volume 3, Issue 2 , June 2023, , Pages 89-97

https://doi.org/10.55705/cmbr.2022.364591.1070

Abstract
  MicroRNAs (miRNA) are a group of small non-coding RNAs that regulate gene expression at the RNA level. MicroRNAs have positive regulatory effects on protein translation processes and often induce their performance by binding to the 3'-UTR mRNA region. Also, microRNAs are involved in various cellular ...  Read More

Comprehensive analysis of microRNA (miRNA) in cancer cells


Medical
Investigating the structure and function of Long Non-Coding RNA (LncRNA) and its role in cancer

Hasan Kamel Alsaedy; Ali Reza Mirzaei; Redha Alwan Hasan Alhashimi

Volume 2, Issue 4 , December 2022, , Pages 245-253

https://doi.org/10.55705/cmbr.2022.360799.1062

Abstract
  Cancer is one of the most complex and common diseases affected by many factors. In recent years, many studies have been conducted on the genetic characteristics of cancer, among which we can mention lncRNA Long Non-Coding RNAs, which effectively eliminate cancer tumors. LncRNAs are non-coding protein ...  Read More

Investigating the structure and function of Long Non-Coding RNA (LncRNA) and its role in cancer


Bioinformatics
Bioinformatics analysis of microtubule-associated protein-1 light chain 3 (MAP1LC3A) and (BECN1) genes in autophagy

Ali Reza Mirzaei; Farzaneh Fazeli

Volume 2, Issue 3 , September 2022, , Pages 129-137

https://doi.org/10.55705/cmbr.2022.345001.1046

Abstract
  Autophagy is an effective regulatory process for eliminating tumors and worn-out intracellular components. Different groups of enzymes and regulatory elements are involved in the autophagy process. MAP1LC3A and BECN1 genes are the most important gene groups in autophagy. These genes, through the production ...  Read More

Bioinformatics analysis of microtubule-associated protein-1 light chain 3 (MAP1LC3A) and (BECN1) genes in autophagy


Bioinformatics
Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes

Ali Reza Mirzaei; Vida Shakoory-Moghadam

Volume 2, Issue 2 , June 2022, , Pages 64-73

https://doi.org/10.55705/cmbr.2022.336232.1035

Abstract
  Different groups of enzymes and regulatory elements are involved in the synthesis of Ribodioside A, which is one of the most important sweetening compounds in stevia. The UGT family (UDP-glycosyltransferase) is a group of regulatory genes that are very effective in converting steviol glycoside to Ribodioside ...  Read More

Bioinformatics analysis and pharmacological effect of Stevia rebaudiana in the prevention of type-2 diabetes


Bioinformatics
Molecular and clinical analysis of genes involved in gastric cancer

Redha Alwan Hasan Alhashimi; Ali Reza Mirzaei; Hasan Kamel Alsaedy

Volume 1, Issue 3 , September 2021, , Pages 138-146

https://doi.org/10.55705/cmbr.2021.355860.1056

Abstract
  Gastric cancer is the abnormal growth of stomach cells. The symptoms of this disease include difficulty in swallowing, heartburn, stomach pain, indigestion, nausea, vomiting, and blood in the stool. Gastric cancer is a multifactorial and genetic disease, and many genes and factors are involved in it. ...  Read More

Molecular and clinical analysis of genes involved in gastric cancer