Medical
Khadije Saravani; Pouya Ostadrahimi; Atena Jahanifard
Abstract
Thalassemia major is the most common hemolytic anemia in Iran and the world that causes an increase in complications in patients, one of the most important of which is liver complications. Therefore, this study aimed to evaluate the level of liver enzymes and their relationship with ferritin and the ...
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Thalassemia major is the most common hemolytic anemia in Iran and the world that causes an increase in complications in patients, one of the most important of which is liver complications. Therefore, this study aimed to evaluate the level of liver enzymes and their relationship with ferritin and the frequency of blood transfusions in patients with thalassemia. This study was performed on 73 patients with thalassemia major. Demographic, clinical and laboratory information were recorded from the medical files. Data were analysed using SPSS version 22 software. Our study showed significant increasing trend in the AST, ALT and ALP levels in thalassemic patients. However, these changes were not statistically significant amount patients with different frequencies of blood transfusion (p>0.05). Among liver enzymes, just AST and ALT had significant correlations with serum ferritin (p<0.001). In addition, serum ferritin levels of more than 1625 mg/dl could predict the abnormal liver enzymes with the highest sensitivity (59%) and specificity (100%) when considering ALT and AST levels as diagnostic measures for liver problems. Due to the high prevalence of liver damage in thalassemia patients, serum ferritin in combination with the other factors can be applied as a suitable index for assessment of the liver function.
Medical
Khadije Saravani; Soleyman Saravani; Fatemeh Dadras
Abstract
Based on the lack of acceptance of screening programs, including breast cancer screening, and cultural-social and economic differences in different regions of our country, the purpose of this research is to determine the attitudinal barriers to breast cancer mammographic screening among women of Zabol ...
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Based on the lack of acceptance of screening programs, including breast cancer screening, and cultural-social and economic differences in different regions of our country, the purpose of this research is to determine the attitudinal barriers to breast cancer mammographic screening among women of Zabol city. The study method is cross-sectional and descriptive-analytical. The statistical population includes 200 women aged over 40 years in Zabol city in 2020 who have not had mammography and were selected by census. The standard questionnaire of professional ethics criteria was used to collect research data. The study data were analyzed using SPSS software. In this study, 200 women were questioned. 5% of women were single and 85.5% were married. 56% of the surveyed women were housewives and 82% employed. 13.5% of women were illiterate and 44.5% university education. The most frequent attitudinal barriers among women were related to the barrier "not having breast cancer symptoms" and "mammography performed by male staff and physicians" so that these two factors were agreed by 75.5% and 49.5% of women, respectively. On the other hand, the lowest frequency of the above factors is related to the three factors "The lack of diagnostic significance of mammography in early cancer diagnosis" with 6% agree and completely agree, and "Not trusting mammography" and "Not trusting national policies and guidelines” with 9% agree and completely agree. Our study revealed the most important factors of reducing motivation among women in the Sistan region regarding mammography. Also, this study showed that women's employment, education and economic status can be effective in their attitude towards mammography.
Medical
Mahsa Keikha; Iraj Shahramian; Khadije Saravani
Abstract
Although liver biopsy is a gold standard for evaluating liver fibrosis, due to the invasive nature of the biopsy and complications related to it in thalassemia major patients, it is important to use new, valid and non-invasive methods to estimate the stage of liver fibrosis. Therefore, this study aimed ...
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Although liver biopsy is a gold standard for evaluating liver fibrosis, due to the invasive nature of the biopsy and complications related to it in thalassemia major patients, it is important to use new, valid and non-invasive methods to estimate the stage of liver fibrosis. Therefore, this study aimed to evaluate the status of non-invasive liver parameters such as FIB-4, APRI, and AAR in thalassemia major patients. The present descriptive-analytical study was conducted in 2019 on patients with thalassemia major. In this study, 140 thalassemia patients were evaluated for demographic findings, liver enzymes and non-invasive indicators of liver fibrosis. Also, underlying diseases such as diabetes, ischemic heart disease and other cases were extracted from patients' medical records. Finally, the data were entered into SPSS V20 software and evaluated. In the present study, 38.6% of the patients were male and the mean age of the patients was 18.47 ± 8.21 years with an age range of 1 to 37 years. Evidence from the present study indicated that patients with thalassemia who had an abnormal liver echo had a significantly higher abnormal APRI index that was consistent with an abnormal liver echo (P = 0.019). However, these items are not applicable for AAR and FIB-4 indicators (P˃0.05). The correlation coefficient of APRI and AAR indices with ALT, AST and ferritin was relatively high and was statistically significant (P˂0.05). Therefore, it can be concluded that these enzymes are well associated with changes in these indices, while there was no significant correlation between the ALKP enzyme and the above indicators. The evidence of the present study showed that non-invasive tests for liver fibrosis including APRI and AAR can have a suitable substitute in assessing the progression of liver fibrosis in thalassemia patients.
Medical
Khadije Saravani; Zahra Mirsarzai; Monireh Sekhavati
Abstract
A cerebral aneurysm is an abnormal bulge in the cerebral artery that spreads where the blood vessel wall has weakened. Cerebral aneurysms may allow blood to leak into the subcutaneous space around the brain and cause damage to brain cells. Brain aneurysms can also be ruptured and can lead to serious ...
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A cerebral aneurysm is an abnormal bulge in the cerebral artery that spreads where the blood vessel wall has weakened. Cerebral aneurysms may allow blood to leak into the subcutaneous space around the brain and cause damage to brain cells. Brain aneurysms can also be ruptured and can lead to serious and possibly fatal strokes. A cerebral aneurysm is known as swelling of a blood vessel in the brain. In the definition of these conditions, it is said that it looks like a hanging berry from a stem. In cases where most aneurysms do not rupture or cause health problems, samples that experience such conditions cause bleeding in the brain - hemorrhagic stroke. Intracranial hemorrhages have attracted much attention because of the increasing role of indirect maternal mortality and the importance of rapid diagnosis and treatment in reducing mortality, and since in many cases, they occur due to brain vascular aneurysm. The topic is also essential. When faced with an aneurysm in a pregnant woman, the decision about pregnancy, termination and termination is based on the indications of midwifery and decision-making about the diagnosis and treatment of aneurysm based on neurosurgical indications.
Medical
Leli Rezaie-Kahkhaie; Khadije Saravani; Khadije Rezaie-Keikhaie; Seyed Esmaeil Azimi-Khatibani; Abdul Hafiz Daman-Sooz; Mehdi Afshari; Atefeh kamali
Abstract
Today, due to the increase in life expectancy in HIV-infected patients, the incidence of related diseases such as hepatitis B and C due to similarity in transmission routes has become a major concern of the health community. Therefore, this study was performed to determine the prevalence of hepatitis ...
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Today, due to the increase in life expectancy in HIV-infected patients, the incidence of related diseases such as hepatitis B and C due to similarity in transmission routes has become a major concern of the health community. Therefore, this study was performed to determine the prevalence of hepatitis B among HIV + patients in Zabol. This descriptive cross-sectional study was performed on 37 HIV-infected patients in Zabol city (2021-2022). In the present study, HIV-infected patients were screened for hepatitis B by measuring serum levels of HBC Ab and HBs Ag. Finally, the data in SPSS V21 software were analyzed. In the present study, a total of 37 HIV-infected patients with a mean age of 40.81- 11.64 years were evaluated. The present study's prevalence of HIV and HCV co-infection was 21.6%. Also, 13.5% of HIV patients had HBV and HCV simultaneously. Examination of risk factors for viral hepatitis in HIV-infected patients showed that unprotected sex (100%), injecting drug use or IDU (87.5%), dental procedures (75%), history of imprisonment (62.5%) and tattooing (50.5%) were the most common factors in HIV patients. Family history of hepatitis B (12.5%), alcohol (12.5%), transfusion (12.5%) and cupping (25%) were among the lowest cases in these patients. the frequency of HBV infection and co-infection with HCV and HBV in HIV-positive patients were relatively high. Except for the history of tattoos, there is no significant relationship between other risk factors and hepatitis B among HIV-positive patients.
Medical
Kolsoum Rezaie-Kahkhaie; Khadije Rezaie-Keikhaie; Leli Rezaie-Kahkhaie; Khadije Saravani; Atefeh kamali
Abstract
The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. This study aimed to investigate the association between IL23R 1142 G/A (Arg381Gln) and GM-CSF 3928 C/T (Ile117Thr) gene polymorphisms with the incidence rate of ...
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The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. This study aimed to investigate the association between IL23R 1142 G/A (Arg381Gln) and GM-CSF 3928 C/T (Ile117Thr) gene polymorphisms with the incidence rate of tuberculosis in the population of Sistan. This study was based on the descriptive and applied type. All patients with active pulmonary tuberculosis were referred to the tuberculosis center of Zabol city for one year, with an equal number of healthy people adapted to the patients examined in terms of age. After data collecting to compare the frequency of polymorphisms, the chi-square test and OR index were used using SPSS software version 16. We have found that the IL23R reduced-function allele 1142A and genotypes CC and TC were overrepresented, especially in the Pad subgroup compared with the control group (44% versus 42%, 21% versus 22%, and 44% versus 39%, respectively. Increased risks of TB with minimal/moderate lung involvement, respectively. Our results demonstrate that the reduced-function polymorphism 1142G ¡ A encoded by IL23R influences the outcome of disease severity of active pulmonary TB in ZABOL patients. The genotypic and allelic frequency of IL23R 1142 G/A, and GM-CSF 3928 C/T (Ile117Thr) polymorphism in patients with tuberculosis was significantly different from the control group and this polymorphism was associated with the incidence of tuberculosis in the population of Sistan.
Cell, Organ and Tissue Culture
Khadije Saravani; Mahdi Afshari; Alireza Aminisefat; Omid Bameri
Abstract
Changes in blood sugar in poisoning can be one of the most important determinants of the outcome of patients with poisoning. Since poisoning is one of the most common and increasing causes of death worldwide and one of the most critical medical emergencies, this study aimed to investigate changes in ...
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Changes in blood sugar in poisoning can be one of the most important determinants of the outcome of patients with poisoning. Since poisoning is one of the most common and increasing causes of death worldwide and one of the most critical medical emergencies, this study aimed to investigate changes in blood sugar in patients with acute poisoning and how patients' blood sugar can predict the severity and outcome of the disease. The present study was performed on 200 patients with acute drug poisoning referred to the emergency department of Amir Al-Momenin Hospital in Zabol from March 2018 to March 2020. Blood glucose levels of all patients were recorded at the time of admission and every hour to the first 5 hours after admission, and the results were entered in the information form of each patient. Finally, the data were entered into SPSS V22 software and statistically analyzed. The mean age of participants was 23.21 ± 12.80 years, and the minimum and maximum age of patients were 1 year and 77 years, respectively, and only 9.8% of them had a history of diabetes. In this study, the highest rate of intoxication with opioids such as methadone and tramadol was (38%), followed by benzodiazepines (20.5%), NSAIDs (19.5%), and SSRIs (7%) were the most commonly used drugs. The prevalence of hypoglycemia in this study was 3% (6 patients), while no cases of hyperglycemia were reported. In this study, most changes in blood sugar were caused by alcohol poisoning. Also, neuroleptics, NSAIDs, and chemicals had the least changes in blood sugar. However, patients' blood sugar at the beginning of poisoning did not affect patients' prognosis. The present study results showed that changes in blood sugar during treatment during drug intoxication, alcohol, medications(sulfonylurea, glibenclamide), and NSAID are very important, so regular monitoring of blood glucose in intoxication with these cases is essential.
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